Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas
Oncogenes involved in recurrent chromosomal translocations serve as diagnostic markers and therapeutic targets in hematopoietic tumors. In contrast to myeloid and B-cell neoplasms, translocations in peripheral T-cell lymphomas (PTCLs) are poorly understood. Here, we identified recurrent translocatio...
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| Veröffentlicht in: | Leukemia 2009-03, Vol.23 (3), p.574-580 |
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| creator | Feldman, A L Law, M Remstein, E D Macon, W R Erickson, L A Grogg, K L Kurtin, P J Dogan, A |
| description | Oncogenes involved in recurrent chromosomal translocations serve as diagnostic markers and therapeutic targets in hematopoietic tumors. In contrast to myeloid and B-cell neoplasms, translocations in peripheral T-cell lymphomas (PTCLs) are poorly understood. Here, we identified recurrent translocations involving the multiple myeloma oncogene-1/interferon regulatory factor-4 (
IRF4
) locus in PTCLs.
IRF4
translocations exist in myeloma and some B-cell lymphomas, but have not been reported earlier in PTCLs. We studied 169 PTCLs using fluorescence
in situ
hybridization and identified 12 cases with
IRF4
translocations. Two cases with t(6;14)(p25;q11.2) had translocations between
IRF4
and the T-cell receptor-alpha (
TCRA
) locus. Both were cytotoxic PTCLs, unspecified (PTCL-Us) involving bone marrow and skin. In total, 8 of the remaining 10 cases were cutaneous anaplastic large-cell lymphomas (ALCLs) without
TCRA
rearrangements (57% of cutaneous ALCLs tested). These findings identified
IRF4
translocations as a novel recurrent genetic abnormality in PTCLs. Cytotoxic PTCL-Us involving bone marrow and skin and containing
IRF4/TCRA
translocations might represent a distinct clinicopathologic entity. Translocations involving
IRF4
but not
TCRA
appear to occur predominantly in cutaneous ALCLs. Detecting these translocations may be useful in lymphoma diagnosis. Further, due to its involvement in translocations, MUM1/IRF4 protein may play an important biologic role in some PTCLs, and might represent a possible therapeutic target. |
| doi_str_mv | 10.1038/leu.2008.320 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2656414</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A195919546</galeid><sourcerecordid>A195919546</sourcerecordid><originalsourceid>FETCH-LOGICAL-c634t-3ce7e27f9d510e997286be5fedcc51fa6f16c92f08db755e3398ab788be9105a3</originalsourceid><addsrcrecordid>eNqFkt9rFDEQxxdR7Fl981kWxT65Z5Ld_HoplNJqoSCU-uBTyOVmb1OyyZnsHvS_N9s72jupSAiBzGe-k5l8i-I9RnOMavHVwTgnCIl5TdCLYoYbzipKKX5ZzJAQvGKSNEfFm5TuEJqC7HVxhIUUnFE-K37dgBljBD-UQ9Q-uWD0YINPpfWb4DbWr8qhg_Lq5rIpgzdhBR7KTI0TUa4h2nUHUbvytjLgXOnu-3UXep3eFq9a7RK8253Hxc_Li9vz79X1j29X52fXlWF1M1S1AQ6Et3JJMQIpORFsAbSFpTEUt5q1mBlJWiSWC04p1LUUesGFWIDEiOr6uDjd6q7HRZ-zciv5OWodba_jvQraqsOIt51ahY0ijLIGN1ngZCcQw-8R0qB6m6ZetIcwJsU4wpxi9l-QIEo4IhP46S_wLozR5ynkog3lDeJ8qvvxn9QklWexJ7XSDpT1bcg9mKmuOsOSyrybiZo_Q-W1hN6a4KG1-f4g4WQvoQPthi4FNz58_SH4ZQuaGFKK0D4OFiM1-U9l_6nJfyr7L-Mf9j_jCd4ZLgOfd4BORrs2e87Y9MgRXCNEuMxcteVSDvkVxKfhPFv4Dxql8Eg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220529976</pqid></control><display><type>article</type><title>Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Feldman, A L ; Law, M ; Remstein, E D ; Macon, W R ; Erickson, L A ; Grogg, K L ; Kurtin, P J ; Dogan, A</creator><creatorcontrib>Feldman, A L ; Law, M ; Remstein, E D ; Macon, W R ; Erickson, L A ; Grogg, K L ; Kurtin, P J ; Dogan, A</creatorcontrib><description>Oncogenes involved in recurrent chromosomal translocations serve as diagnostic markers and therapeutic targets in hematopoietic tumors. In contrast to myeloid and B-cell neoplasms, translocations in peripheral T-cell lymphomas (PTCLs) are poorly understood. Here, we identified recurrent translocations involving the multiple myeloma oncogene-1/interferon regulatory factor-4 (
IRF4
) locus in PTCLs.
IRF4
translocations exist in myeloma and some B-cell lymphomas, but have not been reported earlier in PTCLs. We studied 169 PTCLs using fluorescence
in situ
hybridization and identified 12 cases with
IRF4
translocations. Two cases with t(6;14)(p25;q11.2) had translocations between
IRF4
and the T-cell receptor-alpha (
TCRA
) locus. Both were cytotoxic PTCLs, unspecified (PTCL-Us) involving bone marrow and skin. In total, 8 of the remaining 10 cases were cutaneous anaplastic large-cell lymphomas (ALCLs) without
TCRA
rearrangements (57% of cutaneous ALCLs tested). These findings identified
IRF4
translocations as a novel recurrent genetic abnormality in PTCLs. Cytotoxic PTCL-Us involving bone marrow and skin and containing
IRF4/TCRA
translocations might represent a distinct clinicopathologic entity. Translocations involving
IRF4
but not
TCRA
appear to occur predominantly in cutaneous ALCLs. Detecting these translocations may be useful in lymphoma diagnosis. Further, due to its involvement in translocations, MUM1/IRF4 protein may play an important biologic role in some PTCLs, and might represent a possible therapeutic target.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/leu.2008.320</identifier><identifier>PMID: 18987657</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; B-cell lymphoma ; Biological and medical sciences ; Bone marrow ; Bone Marrow Neoplasms - genetics ; Cancer Research ; Child ; Child, Preschool ; Chromosome aberrations ; Chromosome translocations ; Chromosomes, Human, Pair 14 - genetics ; Chromosomes, Human, Pair 14 - ultrastructure ; Chromosomes, Human, Pair 6 - genetics ; Chromosomes, Human, Pair 6 - ultrastructure ; Cloning ; Critical Care Medicine ; Cytotoxicity ; Diagnosis ; Female ; Fluorescence ; Fluorescence in situ hybridization ; Gene loci ; Genetic aspects ; Genomes ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Hybridization ; In Situ Hybridization, Fluorescence ; Intensive ; Interferon ; Interferon regulatory factor ; Interferon regulatory factor 4 ; Interferon Regulatory Factors - biosynthesis ; Interferon Regulatory Factors - genetics ; Internal Medicine ; Leukemia ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Loci ; Lymphocytes B ; Lymphocytes T ; Lymphoma ; Lymphoma, Primary Cutaneous Anaplastic Large Cell - genetics ; Lymphoma, T-Cell, Cutaneous - genetics ; Lymphoma, T-Cell, Peripheral - genetics ; Male ; Medical genetics ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Multiple myeloma ; Neoplasms ; Oncogene Proteins, Fusion - biosynthesis ; Oncogene Proteins, Fusion - genetics ; Oncogenes ; Oncology ; original-article ; Physiological aspects ; Proteins ; Receptors, Antigen, T-Cell, alpha-beta - genetics ; Risk factors ; Skin ; Skin Neoplasms - genetics ; T cell lymphoma ; T cell receptors ; Therapeutic applications ; Therapeutic targets ; Translocation (Genetics) ; Translocation, Genetic ; Tumors ; Young Adult</subject><ispartof>Leukemia, 2009-03, Vol.23 (3), p.574-580</ispartof><rights>Macmillan Publishers Limited 2009</rights><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2009 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2009</rights><rights>Macmillan Publishers Limited 2009.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c634t-3ce7e27f9d510e997286be5fedcc51fa6f16c92f08db755e3398ab788be9105a3</citedby><cites>FETCH-LOGICAL-c634t-3ce7e27f9d510e997286be5fedcc51fa6f16c92f08db755e3398ab788be9105a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/leu.2008.320$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/leu.2008.320$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21300279$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18987657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feldman, A L</creatorcontrib><creatorcontrib>Law, M</creatorcontrib><creatorcontrib>Remstein, E D</creatorcontrib><creatorcontrib>Macon, W R</creatorcontrib><creatorcontrib>Erickson, L A</creatorcontrib><creatorcontrib>Grogg, K L</creatorcontrib><creatorcontrib>Kurtin, P J</creatorcontrib><creatorcontrib>Dogan, A</creatorcontrib><title>Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>Oncogenes involved in recurrent chromosomal translocations serve as diagnostic markers and therapeutic targets in hematopoietic tumors. In contrast to myeloid and B-cell neoplasms, translocations in peripheral T-cell lymphomas (PTCLs) are poorly understood. Here, we identified recurrent translocations involving the multiple myeloma oncogene-1/interferon regulatory factor-4 (
IRF4
) locus in PTCLs.
IRF4
translocations exist in myeloma and some B-cell lymphomas, but have not been reported earlier in PTCLs. We studied 169 PTCLs using fluorescence
in situ
hybridization and identified 12 cases with
IRF4
translocations. Two cases with t(6;14)(p25;q11.2) had translocations between
IRF4
and the T-cell receptor-alpha (
TCRA
) locus. Both were cytotoxic PTCLs, unspecified (PTCL-Us) involving bone marrow and skin. In total, 8 of the remaining 10 cases were cutaneous anaplastic large-cell lymphomas (ALCLs) without
TCRA
rearrangements (57% of cutaneous ALCLs tested). These findings identified
IRF4
translocations as a novel recurrent genetic abnormality in PTCLs. Cytotoxic PTCL-Us involving bone marrow and skin and containing
IRF4/TCRA
translocations might represent a distinct clinicopathologic entity. Translocations involving
IRF4
but not
TCRA
appear to occur predominantly in cutaneous ALCLs. Detecting these translocations may be useful in lymphoma diagnosis. Further, due to its involvement in translocations, MUM1/IRF4 protein may play an important biologic role in some PTCLs, and might represent a possible therapeutic target.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>B-cell lymphoma</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone Marrow Neoplasms - genetics</subject><subject>Cancer Research</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromosome aberrations</subject><subject>Chromosome translocations</subject><subject>Chromosomes, Human, Pair 14 - genetics</subject><subject>Chromosomes, Human, Pair 14 - ultrastructure</subject><subject>Chromosomes, Human, Pair 6 - genetics</subject><subject>Chromosomes, Human, Pair 6 - ultrastructure</subject><subject>Cloning</subject><subject>Critical Care Medicine</subject><subject>Cytotoxicity</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Fluorescence in situ hybridization</subject><subject>Gene loci</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Hybridization</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Intensive</subject><subject>Interferon</subject><subject>Interferon regulatory factor</subject><subject>Interferon regulatory factor 4</subject><subject>Interferon Regulatory Factors - biosynthesis</subject><subject>Interferon Regulatory Factors - genetics</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Loci</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Lymphoma</subject><subject>Lymphoma, Primary Cutaneous Anaplastic Large Cell - genetics</subject><subject>Lymphoma, T-Cell, Cutaneous - genetics</subject><subject>Lymphoma, T-Cell, Peripheral - genetics</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multiple myeloma</subject><subject>Neoplasms</subject><subject>Oncogene Proteins, Fusion - biosynthesis</subject><subject>Oncogene Proteins, Fusion - genetics</subject><subject>Oncogenes</subject><subject>Oncology</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - genetics</subject><subject>Risk factors</subject><subject>Skin</subject><subject>Skin Neoplasms - genetics</subject><subject>T cell lymphoma</subject><subject>T cell receptors</subject><subject>Therapeutic applications</subject><subject>Therapeutic targets</subject><subject>Translocation (Genetics)</subject><subject>Translocation, Genetic</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkt9rFDEQxxdR7Fl981kWxT65Z5Ld_HoplNJqoSCU-uBTyOVmb1OyyZnsHvS_N9s72jupSAiBzGe-k5l8i-I9RnOMavHVwTgnCIl5TdCLYoYbzipKKX5ZzJAQvGKSNEfFm5TuEJqC7HVxhIUUnFE-K37dgBljBD-UQ9Q-uWD0YINPpfWb4DbWr8qhg_Lq5rIpgzdhBR7KTI0TUa4h2nUHUbvytjLgXOnu-3UXep3eFq9a7RK8253Hxc_Li9vz79X1j29X52fXlWF1M1S1AQ6Et3JJMQIpORFsAbSFpTEUt5q1mBlJWiSWC04p1LUUesGFWIDEiOr6uDjd6q7HRZ-zciv5OWodba_jvQraqsOIt51ahY0ijLIGN1ngZCcQw-8R0qB6m6ZetIcwJsU4wpxi9l-QIEo4IhP46S_wLozR5ynkog3lDeJ8qvvxn9QklWexJ7XSDpT1bcg9mKmuOsOSyrybiZo_Q-W1hN6a4KG1-f4g4WQvoQPthi4FNz58_SH4ZQuaGFKK0D4OFiM1-U9l_6nJfyr7L-Mf9j_jCd4ZLgOfd4BORrs2e87Y9MgRXCNEuMxcteVSDvkVxKfhPFv4Dxql8Eg</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Feldman, A L</creator><creator>Law, M</creator><creator>Remstein, E D</creator><creator>Macon, W R</creator><creator>Erickson, L A</creator><creator>Grogg, K L</creator><creator>Kurtin, P J</creator><creator>Dogan, A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090301</creationdate><title>Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas</title><author>Feldman, A L ; Law, M ; Remstein, E D ; Macon, W R ; Erickson, L A ; Grogg, K L ; Kurtin, P J ; Dogan, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c634t-3ce7e27f9d510e997286be5fedcc51fa6f16c92f08db755e3398ab788be9105a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>B-cell lymphoma</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Bone Marrow Neoplasms - genetics</topic><topic>Cancer Research</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromosome aberrations</topic><topic>Chromosome translocations</topic><topic>Chromosomes, Human, Pair 14 - genetics</topic><topic>Chromosomes, Human, Pair 14 - ultrastructure</topic><topic>Chromosomes, Human, Pair 6 - genetics</topic><topic>Chromosomes, Human, Pair 6 - ultrastructure</topic><topic>Cloning</topic><topic>Critical Care Medicine</topic><topic>Cytotoxicity</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Fluorescence in situ hybridization</topic><topic>Gene loci</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Hybridization</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Intensive</topic><topic>Interferon</topic><topic>Interferon regulatory factor</topic><topic>Interferon regulatory factor 4</topic><topic>Interferon Regulatory Factors - biosynthesis</topic><topic>Interferon Regulatory Factors - genetics</topic><topic>Internal Medicine</topic><topic>Leukemia</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Loci</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Lymphoma</topic><topic>Lymphoma, Primary Cutaneous Anaplastic Large Cell - genetics</topic><topic>Lymphoma, T-Cell, Cutaneous - genetics</topic><topic>Lymphoma, T-Cell, Peripheral - genetics</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multiple myeloma</topic><topic>Neoplasms</topic><topic>Oncogene Proteins, Fusion - biosynthesis</topic><topic>Oncogene Proteins, Fusion - genetics</topic><topic>Oncogenes</topic><topic>Oncology</topic><topic>original-article</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - genetics</topic><topic>Risk factors</topic><topic>Skin</topic><topic>Skin Neoplasms - genetics</topic><topic>T cell lymphoma</topic><topic>T cell receptors</topic><topic>Therapeutic applications</topic><topic>Therapeutic targets</topic><topic>Translocation (Genetics)</topic><topic>Translocation, Genetic</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feldman, A L</creatorcontrib><creatorcontrib>Law, M</creatorcontrib><creatorcontrib>Remstein, E D</creatorcontrib><creatorcontrib>Macon, W R</creatorcontrib><creatorcontrib>Erickson, L A</creatorcontrib><creatorcontrib>Grogg, K L</creatorcontrib><creatorcontrib>Kurtin, P J</creatorcontrib><creatorcontrib>Dogan, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feldman, A L</au><au>Law, M</au><au>Remstein, E D</au><au>Macon, W R</au><au>Erickson, L A</au><au>Grogg, K L</au><au>Kurtin, P J</au><au>Dogan, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>23</volume><issue>3</issue><spage>574</spage><epage>580</epage><pages>574-580</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>Oncogenes involved in recurrent chromosomal translocations serve as diagnostic markers and therapeutic targets in hematopoietic tumors. In contrast to myeloid and B-cell neoplasms, translocations in peripheral T-cell lymphomas (PTCLs) are poorly understood. Here, we identified recurrent translocations involving the multiple myeloma oncogene-1/interferon regulatory factor-4 (
IRF4
) locus in PTCLs.
IRF4
translocations exist in myeloma and some B-cell lymphomas, but have not been reported earlier in PTCLs. We studied 169 PTCLs using fluorescence
in situ
hybridization and identified 12 cases with
IRF4
translocations. Two cases with t(6;14)(p25;q11.2) had translocations between
IRF4
and the T-cell receptor-alpha (
TCRA
) locus. Both were cytotoxic PTCLs, unspecified (PTCL-Us) involving bone marrow and skin. In total, 8 of the remaining 10 cases were cutaneous anaplastic large-cell lymphomas (ALCLs) without
TCRA
rearrangements (57% of cutaneous ALCLs tested). These findings identified
IRF4
translocations as a novel recurrent genetic abnormality in PTCLs. Cytotoxic PTCL-Us involving bone marrow and skin and containing
IRF4/TCRA
translocations might represent a distinct clinicopathologic entity. Translocations involving
IRF4
but not
TCRA
appear to occur predominantly in cutaneous ALCLs. Detecting these translocations may be useful in lymphoma diagnosis. Further, due to its involvement in translocations, MUM1/IRF4 protein may play an important biologic role in some PTCLs, and might represent a possible therapeutic target.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18987657</pmid><doi>10.1038/leu.2008.320</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Leukemia, 2009-03, Vol.23 (3), p.574-580 |
| issn | 0887-6924 1476-5551 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2656414 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Aged, 80 and over B-cell lymphoma Biological and medical sciences Bone marrow Bone Marrow Neoplasms - genetics Cancer Research Child Child, Preschool Chromosome aberrations Chromosome translocations Chromosomes, Human, Pair 14 - genetics Chromosomes, Human, Pair 14 - ultrastructure Chromosomes, Human, Pair 6 - genetics Chromosomes, Human, Pair 6 - ultrastructure Cloning Critical Care Medicine Cytotoxicity Diagnosis Female Fluorescence Fluorescence in situ hybridization Gene loci Genetic aspects Genomes Hematologic and hematopoietic diseases Hematology Humans Hybridization In Situ Hybridization, Fluorescence Intensive Interferon Interferon regulatory factor Interferon regulatory factor 4 Interferon Regulatory Factors - biosynthesis Interferon Regulatory Factors - genetics Internal Medicine Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Loci Lymphocytes B Lymphocytes T Lymphoma Lymphoma, Primary Cutaneous Anaplastic Large Cell - genetics Lymphoma, T-Cell, Cutaneous - genetics Lymphoma, T-Cell, Peripheral - genetics Male Medical genetics Medical sciences Medicine Medicine & Public Health Middle Aged Multiple myeloma Neoplasms Oncogene Proteins, Fusion - biosynthesis Oncogene Proteins, Fusion - genetics Oncogenes Oncology original-article Physiological aspects Proteins Receptors, Antigen, T-Cell, alpha-beta - genetics Risk factors Skin Skin Neoplasms - genetics T cell lymphoma T cell receptors Therapeutic applications Therapeutic targets Translocation (Genetics) Translocation, Genetic Tumors Young Adult |
| title | Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T15%3A41%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Recurrent%20translocations%20involving%20the%20IRF4%20oncogene%20locus%20in%20peripheral%20T-cell%20lymphomas&rft.jtitle=Leukemia&rft.au=Feldman,%20A%20L&rft.date=2009-03-01&rft.volume=23&rft.issue=3&rft.spage=574&rft.epage=580&rft.pages=574-580&rft.issn=0887-6924&rft.eissn=1476-5551&rft.coden=LEUKED&rft_id=info:doi/10.1038/leu.2008.320&rft_dat=%3Cgale_pubme%3EA195919546%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=220529976&rft_id=info:pmid/18987657&rft_galeid=A195919546&rfr_iscdi=true |