Alterations in glucocorticoid negative feedback following maternal Pb, prenatal stress and the combination: A potential biological unifying mechanism for their corresponding disease profiles

Combined exposures to maternal lead (Pb) and prenatal stress (PS) can act synergistically to enhance behavioral and neurochemical toxicity in offspring. Maternal Pb itself causes permanent dysfunction of the body's major stress system, the hypothalamic pituitary adrenal (HPA) axis. The current...

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Veröffentlicht in:	Toxicology and applied pharmacology 2009-01, Vol.234 (1), p.117-127
Hauptverfasser:	Rossi-George, A., Virgolini, M.B., Weston, D., Cory-Slechta, D.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Animals, Newborn Biological and medical sciences BIOLOGICAL STRESS Chemical and industrial products toxicology. Toxic occupational diseases CORTICOSTERONE Corticosterone - blood DEXAMETHASONE Dexamethasone - administration & dosage Dexamethasone - pharmacology Dexamethasone suppression Dose-Response Relationship, Drug DRINKING WATER Female Gender HYPERTENSION Hypothalamic–pituitary–adrenal axis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Lead Lead - administration & dosage Lead - toxicity Male Maternal Exposure Maternal-Fetal Exchange Medical sciences METABOLIC DISEASES Metals and various inorganic compounds Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism Pregnancy Prenatal Exposure Delayed Effects Prenatal stress PROGENY RATS Rats, Long-Evans SCREENING Sex Factors Stress, Physiological Time Factors TOXICITY Toxicology
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