Skeletal Muscle Hypertrophy Following Resistance Training Is Accompanied by a Fiber Type–Specific Increase in Satellite Cell Content in Elderly Men
We determined muscle fiber type–specific hypertrophy and changes in satellite cell (SC) content following a 12-week resistance training program in 13 healthy, elderly men (72 ± 2 years). Leg strength and body composition (dual-energy X-ray absorptiometry and computed tomography) were assessed, and m...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2009-03, Vol.64A (3), p.332-339 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
| container_volume | 64A |
| creator | Verdijk, Lex B. Gleeson, Benjamin G. Jonkers, Richard A. M. Meijer, Kenneth Savelberg, Hans H. C. M. Dendale, Paul van Loon, Luc J. C. |
| description | We determined muscle fiber type–specific hypertrophy and changes in satellite cell (SC) content following a 12-week resistance training program in 13 healthy, elderly men (72 ± 2 years). Leg strength and body composition (dual-energy X-ray absorptiometry and computed tomography) were assessed, and muscle biopsy samples were collected. Leg strength increased 25%–30% after training (p < .001). Leg lean mass and quadriceps cross-sectional area increased 6%–9% (p < .001). At baseline, mean fiber area and SC content were smaller in the Type II versus Type I muscle fibers (p < .01). Following training, Type II muscle fiber area increased from 5,438 ± 319 to 6,982 ± 503 μm2 (p < .01). Type II muscle fiber SC content increased from 0.048 ± 0.003 to 0.084 ± 0.008 SCs per fiber (p < .001). No changes were observed in the Type I muscle fibers. In older adults, skeletal muscle tissue is still capable of inducing SC proliferation and differentiation, resulting in Type II muscle fiber hypertrophy. |
| doi_str_mv | 10.1093/gerona/gln050 |
| format | Article |
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M. ; Meijer, Kenneth ; Savelberg, Hans H. C. M. ; Dendale, Paul ; van Loon, Luc J. C.</creator><creatorcontrib>Verdijk, Lex B. ; Gleeson, Benjamin G. ; Jonkers, Richard A. M. ; Meijer, Kenneth ; Savelberg, Hans H. C. M. ; Dendale, Paul ; van Loon, Luc J. C.</creatorcontrib><description>We determined muscle fiber type–specific hypertrophy and changes in satellite cell (SC) content following a 12-week resistance training program in 13 healthy, elderly men (72 ± 2 years). Leg strength and body composition (dual-energy X-ray absorptiometry and computed tomography) were assessed, and muscle biopsy samples were collected. Leg strength increased 25%–30% after training (p < .001). Leg lean mass and quadriceps cross-sectional area increased 6%–9% (p < .001). At baseline, mean fiber area and SC content were smaller in the Type II versus Type I muscle fibers (p < .01). Following training, Type II muscle fiber area increased from 5,438 ± 319 to 6,982 ± 503 μm2 (p < .01). Type II muscle fiber SC content increased from 0.048 ± 0.003 to 0.084 ± 0.008 SCs per fiber (p < .001). No changes were observed in the Type I muscle fibers. In older adults, skeletal muscle tissue is still capable of inducing SC proliferation and differentiation, resulting in Type II muscle fiber hypertrophy.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/gln050</identifier><identifier>PMID: 19196907</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Absorptiometry, Photon ; Aged ; Aging ; Aging - metabolism ; Aging - physiology ; Analysis of Variance ; Anthropometry ; Biopsy, Needle ; Body Composition ; Diet ; Diet Records ; Exercise ; Humans ; Hypertrophy ; Immunohistochemistry ; Journal of Gerontology: Biological Sciences ; Male ; Muscle Fibers, Skeletal - metabolism ; Muscle Fibers, Skeletal - pathology ; Muscle plasticity ; Muscle Strength - physiology ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - pathology ; Muscular system ; Probability ; Reference Values ; Resistance Training ; Sampling Studies ; Satellite Cells, Skeletal Muscle - metabolism ; Satellite Cells, Skeletal Muscle - pathology ; Tomography ; Tomography, X-Ray Computed</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2009-03, Vol.64A (3), p.332-339</ispartof><rights>The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. 2009</rights><rights>Copyright Gerontological Society of America, Incorporated Mar 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-24e30be983f4819f108ea0398b708559b8d1f4268c785f5a192a642e53d06d823</citedby><cites>FETCH-LOGICAL-c549t-24e30be983f4819f108ea0398b708559b8d1f4268c785f5a192a642e53d06d823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19196907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verdijk, Lex B.</creatorcontrib><creatorcontrib>Gleeson, Benjamin G.</creatorcontrib><creatorcontrib>Jonkers, Richard A. M.</creatorcontrib><creatorcontrib>Meijer, Kenneth</creatorcontrib><creatorcontrib>Savelberg, Hans H. C. M.</creatorcontrib><creatorcontrib>Dendale, Paul</creatorcontrib><creatorcontrib>van Loon, Luc J. C.</creatorcontrib><title>Skeletal Muscle Hypertrophy Following Resistance Training Is Accompanied by a Fiber Type–Specific Increase in Satellite Cell Content in Elderly Men</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>We determined muscle fiber type–specific hypertrophy and changes in satellite cell (SC) content following a 12-week resistance training program in 13 healthy, elderly men (72 ± 2 years). Leg strength and body composition (dual-energy X-ray absorptiometry and computed tomography) were assessed, and muscle biopsy samples were collected. Leg strength increased 25%–30% after training (p < .001). Leg lean mass and quadriceps cross-sectional area increased 6%–9% (p < .001). At baseline, mean fiber area and SC content were smaller in the Type II versus Type I muscle fibers (p < .01). Following training, Type II muscle fiber area increased from 5,438 ± 319 to 6,982 ± 503 μm2 (p < .01). Type II muscle fiber SC content increased from 0.048 ± 0.003 to 0.084 ± 0.008 SCs per fiber (p < .001). No changes were observed in the Type I muscle fibers. In older adults, skeletal muscle tissue is still capable of inducing SC proliferation and differentiation, resulting in Type II muscle fiber hypertrophy.</description><subject>Absorptiometry, Photon</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - metabolism</subject><subject>Aging - physiology</subject><subject>Analysis of Variance</subject><subject>Anthropometry</subject><subject>Biopsy, Needle</subject><subject>Body Composition</subject><subject>Diet</subject><subject>Diet Records</subject><subject>Exercise</subject><subject>Humans</subject><subject>Hypertrophy</subject><subject>Immunohistochemistry</subject><subject>Journal of Gerontology: Biological Sciences</subject><subject>Male</subject><subject>Muscle Fibers, Skeletal - metabolism</subject><subject>Muscle Fibers, Skeletal - pathology</subject><subject>Muscle plasticity</subject><subject>Muscle Strength - physiology</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscular system</subject><subject>Probability</subject><subject>Reference Values</subject><subject>Resistance Training</subject><subject>Sampling Studies</subject><subject>Satellite Cells, Skeletal Muscle - metabolism</subject><subject>Satellite Cells, Skeletal Muscle - pathology</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhUcIREthyRZZLCo2Q-2Z8Yy9QaqihkQk_CVIERvL47mTunXswZ5pyY53QLwgT4KjROVngzfX8v107j0-SfKU4JcE8_xsDd5ZebY2FlN8LzkmFWUpzenqfrzjiqcU4_IoeRTCFd4dmj1MjggnvOS4Ok5-LK7BQC8Nmg9BGUCTbQe-96673KKxM8bdartGHyHo0EurAC291Hb3Ng3oXCm36aTV0KB6iyQa6xo8WkaNn9--LzpQutUKTa3yIAMgbdFC9mCM7gGNYkUjZ3uw_a5zYRrwZovmYB8nD1ppAjw51JPk0_hiOZqks3evp6PzWapowfs0KyDHNXCWtwUjvCWYgcQ5Z3WFGaW8Zg1pi6xkqmK0pZLwTJZFBjRvcNmwLD9JXu11u6HeQKPiJl4a0Xm9kX4rnNTi747Vl2LtbkRW0vivOAqcHgS8-zJA6MVGBxWNSQtuCKKsMOGMFhF8_g945QZvozmRYVZmvCp2ULqHlHcheGjvNiFY7NIW-7TFPu3IP_tz_d_0Id4IvNgDbuj-q3WYHXOGr3ew9NfRRF5RMVl9Fqs3s7dkXnwQ7_NfxJzHzQ</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Verdijk, Lex B.</creator><creator>Gleeson, Benjamin G.</creator><creator>Jonkers, Richard A. M.</creator><creator>Meijer, Kenneth</creator><creator>Savelberg, Hans H. C. M.</creator><creator>Dendale, Paul</creator><creator>van Loon, Luc J. C.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090301</creationdate><title>Skeletal Muscle Hypertrophy Following Resistance Training Is Accompanied by a Fiber Type–Specific Increase in Satellite Cell Content in Elderly Men</title><author>Verdijk, Lex B. ; Gleeson, Benjamin G. ; Jonkers, Richard A. M. ; Meijer, Kenneth ; Savelberg, Hans H. C. M. ; Dendale, Paul ; van Loon, Luc J. 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M.</creatorcontrib><creatorcontrib>Meijer, Kenneth</creatorcontrib><creatorcontrib>Savelberg, Hans H. C. M.</creatorcontrib><creatorcontrib>Dendale, Paul</creatorcontrib><creatorcontrib>van Loon, Luc J. C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verdijk, Lex B.</au><au>Gleeson, Benjamin G.</au><au>Jonkers, Richard A. M.</au><au>Meijer, Kenneth</au><au>Savelberg, Hans H. C. M.</au><au>Dendale, Paul</au><au>van Loon, Luc J. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skeletal Muscle Hypertrophy Following Resistance Training Is Accompanied by a Fiber Type–Specific Increase in Satellite Cell Content in Elderly Men</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>64A</volume><issue>3</issue><spage>332</spage><epage>339</epage><pages>332-339</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>We determined muscle fiber type–specific hypertrophy and changes in satellite cell (SC) content following a 12-week resistance training program in 13 healthy, elderly men (72 ± 2 years). Leg strength and body composition (dual-energy X-ray absorptiometry and computed tomography) were assessed, and muscle biopsy samples were collected. Leg strength increased 25%–30% after training (p < .001). Leg lean mass and quadriceps cross-sectional area increased 6%–9% (p < .001). At baseline, mean fiber area and SC content were smaller in the Type II versus Type I muscle fibers (p < .01). Following training, Type II muscle fiber area increased from 5,438 ± 319 to 6,982 ± 503 μm2 (p < .01). Type II muscle fiber SC content increased from 0.048 ± 0.003 to 0.084 ± 0.008 SCs per fiber (p < .001). No changes were observed in the Type I muscle fibers. In older adults, skeletal muscle tissue is still capable of inducing SC proliferation and differentiation, resulting in Type II muscle fiber hypertrophy.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>19196907</pmid><doi>10.1093/gerona/gln050</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1079-5006 |
| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 2009-03, Vol.64A (3), p.332-339 |
| issn | 1079-5006 1758-535X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2655000 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Absorptiometry, Photon Aged Aging Aging - metabolism Aging - physiology Analysis of Variance Anthropometry Biopsy, Needle Body Composition Diet Diet Records Exercise Humans Hypertrophy Immunohistochemistry Journal of Gerontology: Biological Sciences Male Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - pathology Muscle plasticity Muscle Strength - physiology Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular system Probability Reference Values Resistance Training Sampling Studies Satellite Cells, Skeletal Muscle - metabolism Satellite Cells, Skeletal Muscle - pathology Tomography Tomography, X-Ray Computed |
| title | Skeletal Muscle Hypertrophy Following Resistance Training Is Accompanied by a Fiber Type–Specific Increase in Satellite Cell Content in Elderly Men |
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