Stable synaptic retention of serine-880-phosphorylated GluR2 in hippocampal neurons

Phosphorylation of S880 within the GluR2 C-terminus has been reported to promote endocytosis of AMPA receptors (AMPARs) by preventing GluR2 interaction with the putative synaptic anchoring proteins GRIP and ABP. It is not yet established however, whether S880 phosphorylation induces removal of AMPAR...

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Veröffentlicht in:	Molecular and cellular neuroscience 2008-06, Vol.38 (2), p.189-202
Hauptverfasser:	States, Bradley A., Khatri, Latika, Ziff, Edward B.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPA receptor trafficking Animals Cercopithecus aethiops COS Cells Dendrites - physiology Endocytosis - physiology GluR2 phosphorylation Hippocampus - cytology Mutagenesis Nerve Tissue Proteins - metabolism Neurons - cytology Neurons - metabolism Phosphorylation primary neuronal cultures Protein Kinase C - metabolism Receptors, AMPA - genetics Receptors, AMPA - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism SAP90-PSD95 Associated Proteins Serine - metabolism Sindbis Virus Synapses - metabolism synaptic plasticity Transfection
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