Removal of Hsf4 leads to cataract development in mice through down-regulation of gamma S-crystallin and Bfsp expression

Heat-shock transcription factor 4 (HSF4) mutations are associated with autosomal dominant lamellar cataract and Marner cataract. Disruptions of the Hsf4 gene cause lens defects in mice, indicating a requirement for HSF4 in fiber cell differentiation during lens development. However, neither the rela...

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Veröffentlicht in:	BMC molecular biology 2009-02, Vol.10 (1), p.10-10, Article 10
Hauptverfasser:	Shi, Xiaohe, Cui, Bin, Wang, Zhugang, Weng, Lin, Xu, Zhongping, Ma, Jinjin, Xu, Guotong, Kong, Xiangyin, Hu, Landian
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Crystallin A Chain - metabolism Animals Base Sequence Cataract Cataract - etiology Cataract - genetics Cataract - metabolism Cell Line Developmental biology Disease Models, Animal DNA binding proteins DNA Primers - genetics DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics Down-Regulation Eye Proteins - genetics Female gamma-Crystallins - genetics Genetic aspects Heat Shock Transcription Factors Humans Intermediate Filament Proteins - genetics Lens, Crystalline - abnormalities Lens, Crystalline - growth & development Lens, Crystalline - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Mutation Physiological aspects Pregnancy Protein Processing, Post-Translational RNA, Messenger - genetics RNA, Messenger - metabolism Transcription Factors - deficiency Transcription Factors - genetics
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