Effects of the nicotinic receptor partial agonists varenicline and cytisine on the discriminative stimulus effects of nicotine in rats

The nicotinic partial agonist varenicline (VCL) is a recently approved medication for the treatment of tobacco dependence, yet very little preclinical research on this drug has been published. The present experiment examined the nicotinic partial agonist properties of VCL and its parent compound, cy...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2009-01, Vol.91 (3), p.461-467
Hauptverfasser:	LeSage, Mark G., Shelley, David, Ross, Jason T., Carroll, F. Ivy, Corrigall, William A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Animals Azocines - pharmacology Benzazepines - pharmacology Biological and medical sciences Conditioning, Operant - drug effects Cytisine Data Interpretation, Statistical Discrimination (Psychology) - drug effects Dose-Response Relationship, Drug Drug discrimination Generalization, Stimulus - drug effects Male Medical sciences Nicotine Nicotine - pharmacology Nicotinic Agonists - pharmacology Partial agonist Quinolizines - pharmacology Quinoxalines - pharmacology Rats Rats, Long-Evans Receptors, Nicotinic - drug effects Varenicline α4β2 nicotinic acetlycholine receptor
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