Dual roles of Nrf2 in cancer

In response to oxidative stress, the transcription factor NF-E2-related factor 2 (Nrf2) controls the fate of cells through transcriptional upregulation of antioxidant response element (ARE)-bearing genes, including those encoding endogenous antioxidants, phase II detoxifying enzymes, and transporter...

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Veröffentlicht in:	Pharmacological research 2008-11, Vol.58 (5), p.262-270
Hauptverfasser:	Lau, Alexandria, Villeneuve, Nicole F., Sun, Zheng, Wong, Pak Kin, Zhang, Donna D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ARE Biotransformation - physiology Genes, Switch - genetics Genes, Switch - physiology Glutamate cysteine ligase Glutathione peroxidase Glutathione S-transferase Heme oxygenase Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - physiology Keap1 Kelch-Like ECH-Associated Protein 1 MRP NAD(P)H quinone oxidoreductase-1 Neoplasms - genetics Neoplasms - pathology Neoplasms - prevention & control NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - physiology Nrf2 Peroxiredoxin Thioredoxin reductase
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