Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2

Lapatinib is active at the ATP-binding site of tyrosine kinases that are associated with the human epidermal growth factor receptor (Her-1 or ErbB1) and Her-2. It is conceivable that lapatinib may inhibit the function of ATP-binding cassette (ABC) transporters by binding to their ATP-binding sites....

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-10, Vol.68 (19), p.7905-7914
Hauptverfasser:	DAI, Chun-Ling, TIWARI, Amit K, CHEN, Li-Ming, SHI, Cheng-Jun, AMBUDKAR, Suresh V, CHEN, Zhe-Sheng, FU, Li-Wu, WU, Chung-Pu, SU, Xiao-Dong, WANG, Si-Rong, LIU, Dong-Geng, ASHBY, Charles R, YAN HUANG, ROBEY, Robert W, LIANG, Yong-Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - drug effects Adenosine Triphosphatases - metabolism Animals Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use ATP Binding Cassette Transporter, Sub-Family B ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Cells, Cultured Dose-Response Relationship, Drug Drug Resistance, Multiple - drug effects Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic - drug effects Humans Medical sciences Mice Mice, Nude Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Paclitaxel - administration & dosage Paclitaxel - pharmacokinetics Pharmacology. Drug treatments Quinazolines - administration & dosage Quinazolines - pharmacokinetics Quinazolines - pharmacology Transfection Tumor Burden - drug effects Tumors Up-Regulation - drug effects Up-Regulation - physiology Xenograft Model Antitumor Assays
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