The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of Its Chemical Properties
The first synthesis of a novel 5:7:5-fused heterocyclic ring system, a diimidazodiazepine, is reported. The propensity of the ring system to undergo facile, acid-catalyzed nucleophilic addition reactions by neutral carbon and nitrogen nucleophiles has been explored. The ring system has potential fut...
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| Veröffentlicht in: | Organic letters 2008-10, Vol.10 (20), p.4681-4684 |
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| container_title | Organic letters |
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| creator | Kumar, Raj Ujjinamatada, Ravi K Hosmane, Ramachandra S |
| description | The first synthesis of a novel 5:7:5-fused heterocyclic ring system, a diimidazodiazepine, is reported. The propensity of the ring system to undergo facile, acid-catalyzed nucleophilic addition reactions by neutral carbon and nitrogen nucleophiles has been explored. The ring system has potential future applications in mechanistic studies of formation and repair of DNA interstrand cross-links. |
| doi_str_mv | 10.1021/ol8020176 |
| format | Article |
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The ring system has potential future applications in mechanistic studies of formation and repair of DNA interstrand cross-links.</description><subject>Azepines - chemical synthesis</subject><subject>Azepines - chemistry</subject><subject>Imidazoles - chemistry</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Molecular Structure</subject><issn>1523-7060</issn><issn>1523-7052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU1v1DAQhi1URD_gwB9AvhSph8CME-ejByS0dEulChAtZ2uSTLquknhrJ5XaX19Xu9qCxGlGM8-89swrxHuETwgKP7u-BAVY5K_EAWqVJgVotbfLc9gXhyHcAmCsVG_EPpYl5qjKAzFcr1gurQ-TvHoYpxUHG6TrJMkf7p57qU-LU50s58Ct_GbtYFt6dK2lR17bkeVvO97EwTDxIGls5ZUb-Hn8YgpyseLBNtTLX96t2U-Ww1vxuqM-8LttPBJ_lmfXi-_J5c_zi8XXy4QySKek05hWKYHGJiVi7krQpaqyrAbMqxRYU9ykwwIUIala1V1eQ1N0ZYFtVWfpkfiy0V3P9cBtw-PkqTdrbwfyD8aRNf92RrsyN-7eqFwryNIo8HEr4N3dzGEygw0N9z2N7OZg8iqPFBYRPNmAjXcheO52jyCYZ3PMzpzIfvj7Vy_k1o0IHG8AaoK5dbMf45H-I_QETieVjw</recordid><startdate>20081016</startdate><enddate>20081016</enddate><creator>Kumar, Raj</creator><creator>Ujjinamatada, Ravi K</creator><creator>Hosmane, Ramachandra S</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081016</creationdate><title>The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of Its Chemical Properties</title><author>Kumar, Raj ; Ujjinamatada, Ravi K ; Hosmane, Ramachandra S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a403t-f51393a051c3aaeef80582944b016930e5a115f1702a1a2b2bf6b0c7f871d9b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Azepines - chemical synthesis</topic><topic>Azepines - chemistry</topic><topic>Imidazoles - chemistry</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Molecular Structure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumar, Raj</creatorcontrib><creatorcontrib>Ujjinamatada, Ravi K</creatorcontrib><creatorcontrib>Hosmane, Ramachandra S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Organic letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumar, Raj</au><au>Ujjinamatada, Ravi K</au><au>Hosmane, Ramachandra S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of Its Chemical Properties</atitle><jtitle>Organic letters</jtitle><addtitle>Org. Lett</addtitle><date>2008-10-16</date><risdate>2008</risdate><volume>10</volume><issue>20</issue><spage>4681</spage><epage>4684</epage><pages>4681-4684</pages><issn>1523-7060</issn><eissn>1523-7052</eissn><abstract>The first synthesis of a novel 5:7:5-fused heterocyclic ring system, a diimidazodiazepine, is reported. The propensity of the ring system to undergo facile, acid-catalyzed nucleophilic addition reactions by neutral carbon and nitrogen nucleophiles has been explored. The ring system has potential future applications in mechanistic studies of formation and repair of DNA interstrand cross-links.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>18816128</pmid><doi>10.1021/ol8020176</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Azepines - chemical synthesis Azepines - chemistry Imidazoles - chemistry Magnetic Resonance Spectroscopy Molecular Structure |
| title | The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of Its Chemical Properties |
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