The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of Its Chemical Properties

The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of Its Chemical Properties

The first synthesis of a novel 5:7:5-fused heterocyclic ring system, a diimidazodiazepine, is reported. The propensity of the ring system to undergo facile, acid-catalyzed nucleophilic addition reactions by neutral carbon and nitrogen nucleophiles has been explored. The ring system has potential fut...

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Veröffentlicht in:Organic letters 2008-10, Vol.10 (20), p.4681-4684
Hauptverfasser: Kumar, Raj, Ujjinamatada, Ravi K, Hosmane, Ramachandra S
Format: Artikel
Sprache:eng
Schlagworte:
Azepines - chemical synthesis
Azepines - chemistry
Imidazoles - chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
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Zusammenfassung:The first synthesis of a novel 5:7:5-fused heterocyclic ring system, a diimidazodiazepine, is reported. The propensity of the ring system to undergo facile, acid-catalyzed nucleophilic addition reactions by neutral carbon and nitrogen nucleophiles has been explored. The ring system has potential future applications in mechanistic studies of formation and repair of DNA interstrand cross-links.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol8020176