HTRA1 promoter polymorphism predisposes Japanese to age-related macular degeneration

To study the effect of candidate single nucleotide polymorphisms (SNPs) on chromosome 10q26, recently shown to be associated with wet age-related macular degeneration (AMD) in Chinese and Caucasian cohorts, in a Japanese cohort. Using genomic DNA isolated from peripheral blood of wet AMD cases and a...

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Veröffentlicht in:	Molecular vision 2007-04, Vol.13, p.545-548
Hauptverfasser:	Yoshida, Tsunehiko, DeWan, Andrew, Zhang, Hong, Sakamoto, Ryosuke, Okamoto, Haru, Minami, Masayoshi, Obazawa, Minoru, Mizota, Atsushi, Tanaka, Minoru, Saito, Yoshihiro, Takagi, Ikue, Hoh, Josephine, Iwata, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alleles Asian People - genetics Cohort Studies Complement Factor H - genetics Conserved Sequence Female Gene Dosage Genes, Recessive Genetic Predisposition to Disease Genotype High-Temperature Requirement A Serine Peptidase 1 Histidine Humans Linkage Disequilibrium Macular Degeneration - genetics Male Middle Aged Odds Ratio Polymorphism, Genetic Polymorphism, Single Nucleotide Serine Endopeptidases - genetics Tyrosine
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