Cyclin A-Cdk1 regulates the origin firing program in mammalian cells

Somatic mammalian cells possess well-established S-phase programs with specific regions of the genome replicated at precise times. The ATR-Chk1 pathway plays a central role in these programs, but the mechanism for how Chk1 regulates origin firing remains unknown. We demonstrate here the essential ro...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-03, Vol.106 (9), p.3184-3189
Hauptverfasser:	Katsuno, Yuko, Suzuki, Ayumi, Sugimura, Kazuto, Okumura, Katsuzumi, Zineldeen, Doaa H, Shimada, Midori, Niida, Hiroyuki, Mizuno, Takeshi, Hanaoka, Fumio, Nakanishi, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Antibodies Biological Sciences CDC2 Protein Kinase - deficiency CDC2 Protein Kinase - genetics CDC2 Protein Kinase - metabolism Cell cycle Cell Line Cell lines Cells Cyclin A - genetics Cyclin A - metabolism Cyclins Deoxyribonucleic acid DNA DNA replication Enzyme Activation Gene expression Gene expression regulation HeLa cells Humans Interphase Kinetics Mammals Mice Mice, Knockout Mutation Mutation - drug effects Protein Binding Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Replication origin S Phase
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