Induced Association of μ Opioid (MOP) and Type 2 Cholecystokinin (CCK2) Receptors by Novel Bivalent Ligands

Both μ-opioid (MOP) and type 2 cholecystokinin (CCK2) receptors are present in areas of the central nervous system that are involved in modulation of pain processing. We conducted bioluminescence resonance energy transfer (BRET) studies on COS cells coexpressing MOP and CCK2 receptors to determine w...

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Veröffentlicht in:	Journal of medicinal chemistry 2009-01, Vol.52 (2), p.247-258
Hauptverfasser:	Zheng, Yaguo, Akgün, Eyup, Harikumar, Kaleeckal G, Hopson, Jessika, Powers, Michael D, Lunzer, Mary M, Miller, Laurence J, Portoghese, Philip S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Biological and medical sciences Cercopithecus aethiops CHO Cells COS Cells Cricetinae Cricetulus Dimerization Energy Transfer Ligands Magnetic Resonance Spectroscopy Medical sciences Mice Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Protein Binding Receptor, Cholecystokinin B - metabolism Receptors, Opioid, mu - metabolism
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