Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

Smoothened (Smo), a 7-pass transmembrane protein, is essential for transduction of a Hedgehog (Hh) signal across the cell membrane. Smo is also the principle therapeutic target for several candidate drugs in the treatment of Hh-related diseases. Mammalian Smo translocates to the primary cilium in re...

Ausführliche Beschreibung