Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism

Phosphomevalonate kinase (PMK) catalyzes an essential step in the mevalonate pathway, which is the only pathway for synthesis of isoprenoids and steroids in humans. PMK catalyzes transfer of the γ‐phosphate of ATP to mevalonate 5‐phosphate (M5P) to form mevalonate 5‐diphosphate. Bringing these phosp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2009-04, Vol.75 (1), p.127-138
Hauptverfasser:	Olson, Andrew L., Yao, Huili, Herdendorf, Timothy J., Miziorko, Henry M., Hannongbua, Supa, Saparpakorn, Patchareenart, Cai, Sheng, Sem, Daniel S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism chemical shift perturbation Humans mevalonate Mevalonic Acid - analogs & derivatives Mevalonic Acid - metabolism modelfree Models, Molecular NMR Nuclear Magnetic Resonance, Biomolecular phosphomevalonate kinase Phosphotransferases (Phosphate Group Acceptor) - chemistry Phosphotransferases (Phosphate Group Acceptor) - metabolism Protein Binding Protein Conformation relaxation dynamics Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!