Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-specific Functions

Biological experiments are most often performed with immortalized cell lines because they are readily available and can be expanded without limitation. However, cell lines may differ from the in vivo situation in important aspects. Here we introduce a straightforward methodology to compare cell line...

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Veröffentlicht in:	Molecular & cellular proteomics 2009-03, Vol.8 (3), p.443-450
Hauptverfasser:	Pan, Cuiping, Kumar, Chanchal, Bohl, Sebastian, Klingmueller, Ursula, Mann, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cells, Cultured Hepatocytes - cytology Hepatocytes - metabolism Mice Organ Specificity Phenotype Proteome - metabolism Proteomics - methods
Online-Zugang:	Volltext
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