Perioperative management of aspirin resistance after off-pump coronary artery bypass grafting: possible role for aprotinin

BACKGROUND: Aspirin is the only drug proven to reduce saphenous vein graft (SVG) failure, but aspirin resistance (ASA‐R) frequently occurs after off‐pump coronary artery bypass grafting (OPCAB). The factors, mechanism, and best means for preventing and/or treating ASA‐R have not been established. Th...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2008-03, Vol.48 (s1), p.39S-46S
Hauptverfasser:	Poston, Robert S., Gu, Junyan, White, Charles, Jeudy, Jean, Nie, Lei, Brown, James, Gammie, James, Pierson, Richard N., Romar, Linda, Griffith, Bartley P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aprotinin - pharmacology Aprotinin - therapeutic use Aspirin - therapeutic use Blood Coagulation - drug effects Blood Coagulation - physiology Cohort Studies Coronary Artery Bypass, Off-Pump - adverse effects Drug Resistance - drug effects Fibrinolytic Agents - therapeutic use Follow-Up Studies Graft Survival - drug effects Hemostatics - pharmacology Hemostatics - therapeutic use Humans Perioperative Care - methods Platelet Activation Thromboplastin - metabolism
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