Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

siRNAs that specifically silence the expression of cancer-related genes offer a therapeutic approach in oncology. However, it remains critical to determine the true mechanism of their therapeutic effects. Here, we describe the preclinical development of chemically modified siRNA targeting the essent...

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Veröffentlicht in:	The Journal of clinical investigation 2009-03, Vol.119 (3), p.661-673
Hauptverfasser:	Judge, Adam D, Robbins, Marjorie, Tavakoli, Iran, Levi, Jasna, Hu, Lina, Fronda, Anna, Ambegia, Ellen, McClintock, Kevin, MacLachlan, Ian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomedical research Cancer Care and treatment Cell Cycle Proteins - genetics Cytokines Disease Models, Animal Gene Duplication Gene silencing Genes Genetic aspects Genetic Therapy Incorporation Kinases Lipids Methods Mice Neoplasms - genetics Neoplasms - therapy Neoplasms, Experimental - genetics Neoplasms, Experimental - pathology Oncology Physiological aspects Polo-Like Kinase 1 Polymerase Chain Reaction Protein Serine-Threonine Kinases - deficiency Protein Serine-Threonine Kinases - genetics Proteins Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - genetics RNA Interference RNA, Messenger - genetics RNA, Neoplasm - genetics RNA, Small Interfering - genetics Technical Advance Tumors Vehicles
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