Activation of the Ubiquitin-Proteasome Pathway in the Diaphragm in Chronic Obstructive Pulmonary Disease

Studies show that the myosin content of the diaphragm in patients with mild to moderate chronic obstructive pulmonary disease (COPD) is reduced, compromising diaphragm contractile performance. The mechanisms for reduced contractile protein content are unknown. In the present study we hypothesized th...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2006-11, Vol.174 (9), p.997-1002
Hauptverfasser:	Ottenheijm, Coen A. C, Heunks, Leo M. A, Li, Yi-Ping, Jin, Bingwen, Minnaard, Ronnie, van Hees, Hieronymus W. H, Dekhuijzen, P. N. Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biopsy C. Chronic Obstructive Pulmonary Disease Caspase 3 - metabolism Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma Diaphragm (Anatomy) Diaphragm - chemistry Diaphragm - metabolism Enzymes Female Humans Immunohistochemistry Intensive care medicine Lung diseases Male Medical sciences Middle Aged Muscle Contraction - physiology Muscle Proteins - metabolism Myosins - metabolism Neuromuscular diseases Ostomy Patients Pneumology Polymerase chain reaction Proteasome Endopeptidase Complex - metabolism Proteins Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases SKP Cullin F-Box Protein Ligases - metabolism Tripartite Motif Proteins Ubiquitin - metabolism Ubiquitin-Protein Ligases - metabolism
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