c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection

Abstract Cyclic diguanylate (c-di-GMP) is a unique bacterial intracellular signaling molecule capable of stimulating enhanced protective innate immunity against various bacterial infections. The effects of intranasal pretreatment with c-di-GMP, or intraperitoneal coadministration of c-di-GMP with th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2008-08, Vol.26 (36), p.4676-4685
Hauptverfasser:	Ogunniyi, Abiodun D, Paton, James C, Kirby, Alun C, McCullers, Jonathan A, Cook, Jan, Hyodo, Mamoru, Hayakawa, Yoshihiro, Karaolis, David K.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - pharmacology Administration, Intranasal Allergy and Immunology Alum Compounds - administration & dosage Animals Antibodies, Bacterial - blood Antigens Applied microbiology Bacterial diseases Bacterial infections Bacterial Proteins - immunology Bacteriology Biological and medical sciences Blood - microbiology c-di-GMP Cloning Colony Count, Microbial Cyclic GMP - analogs & derivatives Cyclic GMP - pharmacology Ear diseases Female Fundamental and applied biological sciences. Psychology Human bacterial diseases Immune system Immunologic Factors - administration & dosage Immunologic Factors - pharmacology Immunomodulator Infectious diseases Injections, Intraperitoneal Lung - immunology Lung - microbiology Lymph nodes Lymph Nodes - immunology Male Medical sciences Mice Mice, Inbred BALB C Microbiology Miscellaneous Mortality Pneumococcal Infections - prevention & control Pneumococcal Vaccines - immunology Pneumonia Proteins Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - growth & development Streptococcus pneumoniae - immunology Streptolysins - immunology Studies Survival Analysis Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!