B7-H4–deficient mice display augmented neutrophil-mediated innate immunity

B7-H4 is an immunoglobulin superfamily molecule and shown to be inhibitory for T-cell responses. To explore physiologic roles of B7-H4, we created B7-H4–deficient (KO) mice by genetic targeting. B7-H4KO mice are healthy and their T- and B-cell responses to polyclonal antigens are in normal range. Ho...

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Veröffentlicht in:	Blood 2009-02, Vol.113 (8), p.1759-1767
Hauptverfasser:	Zhu, Gefeng, Augustine, Mathew M., Azuma, Takeshi, Luo, Liqun, Yao, Sheng, Anand, Sudarshan, Rietz, A. Cecilia, Huang, Jiaqiang, Xu, Haiying, Flies, Andrew S., Flies, Sarah J., Tamada, Koji, Colonna, Marco, van Deursen, Jan M.A., Chen, Lieping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - immunology B-Lymphocytes - microbiology B7-1 Antigen - genetics B7-1 Antigen - immunology Bacteriology Biological and medical sciences Bone Marrow Cells - cytology CD11b Antigen - metabolism Female Fundamental and applied biological sciences. Psychology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Listeriosis - immunology Male Mice Mice, Inbred Strains Mice, Knockout Microbiology Neutrophils - immunology Neutrophils - microbiology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Phagocytes, Granulocytes, and Myelopoiesis Phagocytosis - immunology Receptors, Chemokine - metabolism Respiratory Burst - immunology T-Lymphocytes - immunology T-Lymphocytes - microbiology V-Set Domain-Containing T-Cell Activation Inhibitor 1
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