Hepatitis B vaccine: further studies in children with previously acquired hepatitis B surface antigenemia

Hepatitis B vaccine: further studies in children with previously acquired hepatitis B surface antigenemia

Three doses of inactivated hepatitis B vaccine were given at 1-month intervals to 31 hepatitis B surface antigen (HBsAg)-positive Senegalese children aged between 3 and 24 months. A control group of 18 HBsAg-positive Senegalese children received diphtheria-tetanus-polio vaccine. Immunization of HBsA...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Infection and immunity 1983-07, Vol.41 (1), p.83-87
Hauptverfasser: Barin, F, Yvonnet, B, Goudeau, A, Coursaget, P, Chiron, J P, Denis, F, Mar, I D
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 87
container_issue 1
container_start_page 83
container_title Infection and immunity
container_volume 41
creator Barin, F
Yvonnet, B
Goudeau, A
Coursaget, P
Chiron, J P
Denis, F
Mar, I D
description Three doses of inactivated hepatitis B vaccine were given at 1-month intervals to 31 hepatitis B surface antigen (HBsAg)-positive Senegalese children aged between 3 and 24 months. A control group of 18 HBsAg-positive Senegalese children received diphtheria-tetanus-polio vaccine. Immunization of HBsAg-positive infants with hepatitis B vaccine was safe but inefficient. After a 12-month follow-up, the prevalence of HBsAg chronic carriers was not significantly reduced in the hepatitis B vaccine group as compared with the control group: 48.4 and 66.7%, respectively. The presence of hepatitis B antigen was found to be a major risk factor for HBsAg-positive children to develop a chronic carrier state. The risk of developing an HBsAg chronic carrier state was also related to advancing age at time of enrollment in the study.
format Article
fullrecord <record><control><sourceid>pubmedcentral</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_264746</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>pubmedcentral_primary_oai_pubmedcentral_nih_gov_264746</sourcerecordid><originalsourceid>FETCH-pubmedcentral_primary_oai_pubmedcentral_nih_gov_2647463</originalsourceid><addsrcrecordid>eNqljE1OwzAQRi0EgpRyh7lAJMc4aY3EBgTqAdhbgzOpp0qc4J-g3h4WLGDN6tPT0_suRNVIs6_bVqlLUUnZmNq03e5GbFI6faPWen8tNlLKTillTFMJPtCCmTMneIIVneNADzCUmD1FSLn0TAk4gPM89pECfHL2sERaeS5pPAO6j8KRevC_nlKJAzoCDJmPFGhi3IqrAcdEdz97Kx5fX96eD_VS3ifqHYUccbRL5Anj2c7I9q8J7O1xXq3q9E539__tvwDnh2MZ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Hepatitis B vaccine: further studies in children with previously acquired hepatitis B surface antigenemia</title><source>American Society for Microbiology</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Barin, F ; Yvonnet, B ; Goudeau, A ; Coursaget, P ; Chiron, J P ; Denis, F ; Mar, I D</creator><creatorcontrib>Barin, F ; Yvonnet, B ; Goudeau, A ; Coursaget, P ; Chiron, J P ; Denis, F ; Mar, I D</creatorcontrib><description>Three doses of inactivated hepatitis B vaccine were given at 1-month intervals to 31 hepatitis B surface antigen (HBsAg)-positive Senegalese children aged between 3 and 24 months. A control group of 18 HBsAg-positive Senegalese children received diphtheria-tetanus-polio vaccine. Immunization of HBsAg-positive infants with hepatitis B vaccine was safe but inefficient. After a 12-month follow-up, the prevalence of HBsAg chronic carriers was not significantly reduced in the hepatitis B vaccine group as compared with the control group: 48.4 and 66.7%, respectively. The presence of hepatitis B antigen was found to be a major risk factor for HBsAg-positive children to develop a chronic carrier state. The risk of developing an HBsAg chronic carrier state was also related to advancing age at time of enrollment in the study.</description><identifier>ISSN: 0019-9567</identifier><identifier>EISSN: 1098-5522</identifier><identifier>PMID: 0006222991</identifier><identifier>PMID: 6222991</identifier><language>eng</language><ispartof>Infection and immunity, 1983-07, Vol.41 (1), p.83-87</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC264746/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC264746/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,53772,53774</link.rule.ids></links><search><creatorcontrib>Barin, F</creatorcontrib><creatorcontrib>Yvonnet, B</creatorcontrib><creatorcontrib>Goudeau, A</creatorcontrib><creatorcontrib>Coursaget, P</creatorcontrib><creatorcontrib>Chiron, J P</creatorcontrib><creatorcontrib>Denis, F</creatorcontrib><creatorcontrib>Mar, I D</creatorcontrib><title>Hepatitis B vaccine: further studies in children with previously acquired hepatitis B surface antigenemia</title><title>Infection and immunity</title><description>Three doses of inactivated hepatitis B vaccine were given at 1-month intervals to 31 hepatitis B surface antigen (HBsAg)-positive Senegalese children aged between 3 and 24 months. A control group of 18 HBsAg-positive Senegalese children received diphtheria-tetanus-polio vaccine. Immunization of HBsAg-positive infants with hepatitis B vaccine was safe but inefficient. After a 12-month follow-up, the prevalence of HBsAg chronic carriers was not significantly reduced in the hepatitis B vaccine group as compared with the control group: 48.4 and 66.7%, respectively. The presence of hepatitis B antigen was found to be a major risk factor for HBsAg-positive children to develop a chronic carrier state. The risk of developing an HBsAg chronic carrier state was also related to advancing age at time of enrollment in the study.</description><issn>0019-9567</issn><issn>1098-5522</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><recordid>eNqljE1OwzAQRi0EgpRyh7lAJMc4aY3EBgTqAdhbgzOpp0qc4J-g3h4WLGDN6tPT0_suRNVIs6_bVqlLUUnZmNq03e5GbFI6faPWen8tNlLKTillTFMJPtCCmTMneIIVneNADzCUmD1FSLn0TAk4gPM89pECfHL2sERaeS5pPAO6j8KRevC_nlKJAzoCDJmPFGhi3IqrAcdEdz97Kx5fX96eD_VS3ifqHYUccbRL5Anj2c7I9q8J7O1xXq3q9E539__tvwDnh2MZ</recordid><startdate>19830701</startdate><enddate>19830701</enddate><creator>Barin, F</creator><creator>Yvonnet, B</creator><creator>Goudeau, A</creator><creator>Coursaget, P</creator><creator>Chiron, J P</creator><creator>Denis, F</creator><creator>Mar, I D</creator><scope>5PM</scope></search><sort><creationdate>19830701</creationdate><title>Hepatitis B vaccine: further studies in children with previously acquired hepatitis B surface antigenemia</title><author>Barin, F ; Yvonnet, B ; Goudeau, A ; Coursaget, P ; Chiron, J P ; Denis, F ; Mar, I D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmedcentral_primary_oai_pubmedcentral_nih_gov_2647463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barin, F</creatorcontrib><creatorcontrib>Yvonnet, B</creatorcontrib><creatorcontrib>Goudeau, A</creatorcontrib><creatorcontrib>Coursaget, P</creatorcontrib><creatorcontrib>Chiron, J P</creatorcontrib><creatorcontrib>Denis, F</creatorcontrib><creatorcontrib>Mar, I D</creatorcontrib><collection>PubMed Central (Full Participant titles)</collection><jtitle>Infection and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barin, F</au><au>Yvonnet, B</au><au>Goudeau, A</au><au>Coursaget, P</au><au>Chiron, J P</au><au>Denis, F</au><au>Mar, I D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis B vaccine: further studies in children with previously acquired hepatitis B surface antigenemia</atitle><jtitle>Infection and immunity</jtitle><date>1983-07-01</date><risdate>1983</risdate><volume>41</volume><issue>1</issue><spage>83</spage><epage>87</epage><pages>83-87</pages><issn>0019-9567</issn><eissn>1098-5522</eissn><abstract>Three doses of inactivated hepatitis B vaccine were given at 1-month intervals to 31 hepatitis B surface antigen (HBsAg)-positive Senegalese children aged between 3 and 24 months. A control group of 18 HBsAg-positive Senegalese children received diphtheria-tetanus-polio vaccine. Immunization of HBsAg-positive infants with hepatitis B vaccine was safe but inefficient. After a 12-month follow-up, the prevalence of HBsAg chronic carriers was not significantly reduced in the hepatitis B vaccine group as compared with the control group: 48.4 and 66.7%, respectively. The presence of hepatitis B antigen was found to be a major risk factor for HBsAg-positive children to develop a chronic carrier state. The risk of developing an HBsAg chronic carrier state was also related to advancing age at time of enrollment in the study.</abstract><pmid>0006222991</pmid><pmid>6222991</pmid></addata></record>
fulltext fulltext
identifier ISSN: 0019-9567
ispartof Infection and immunity, 1983-07, Vol.41 (1), p.83-87
issn 0019-9567
1098-5522
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_264746
source American Society for Microbiology; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
title Hepatitis B vaccine: further studies in children with previously acquired hepatitis B surface antigenemia
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T13%3A11%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmedcentral&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hepatitis%20B%20vaccine:%20further%20studies%20in%20children%20with%20previously%20acquired%20hepatitis%20B%20surface%20antigenemia&rft.jtitle=Infection%20and%20immunity&rft.au=Barin,%20F&rft.date=1983-07-01&rft.volume=41&rft.issue=1&rft.spage=83&rft.epage=87&rft.pages=83-87&rft.issn=0019-9567&rft.eissn=1098-5522&rft_id=info:doi/&rft_dat=%3Cpubmedcentral%3Epubmedcentral_primary_oai_pubmedcentral_nih_gov_264746%3C/pubmedcentral%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/0006222991&rfr_iscdi=true