why and how of DNA unlinking
The nucleotide sequence of DNA is the repository of hereditary information. Yet, it is now clear that the DNA itself plays an active role in regulating the ability of the cell to extract its information. Basic biological processes, including control of gene transcription, faithful DNA replication an...
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| Veröffentlicht in: | Nucleic acids research 2009-02, Vol.37 (3), p.661-671 |
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| container_title | Nucleic acids research |
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| creator | Liu, Zhirong Deibler, Richard W Chan, Hue Sun Zechiedrich, Lynn |
| description | The nucleotide sequence of DNA is the repository of hereditary information. Yet, it is now clear that the DNA itself plays an active role in regulating the ability of the cell to extract its information. Basic biological processes, including control of gene transcription, faithful DNA replication and segregation, maintenance of the genome and cellular differentiation are subject to the conformational and topological properties of DNA in addition to the regulation imparted by the sequence itself. How do these DNA features manifest such striking effects and how does the cell regulate them? In this review, we describe how misregulation of DNA topology can lead to cellular dysfunction. We then address how cells prevent these topological problems. We close with a discussion on recent theoretical advances indicating that the topological problems, themselves, can provide the cues necessary for their resolution by type-2 topoisomerases. |
| doi_str_mv | 10.1093/nar/gkp041 |
| format | Article |
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We close with a discussion on recent theoretical advances indicating that the topological problems, themselves, can provide the cues necessary for their resolution by type-2 topoisomerases.</description><identifier>ISSN: 0305-1048</identifier><identifier>EISSN: 1362-4962</identifier><identifier>DOI: 10.1093/nar/gkp041</identifier><identifier>PMID: 19240147</identifier><identifier>CODEN: NARHAD</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>DNA - chemistry ; DNA - metabolism ; DNA Topoisomerases, Type II - metabolism ; Models, Molecular ; Nucleic Acid Conformation ; Survey and Summary</subject><ispartof>Nucleic acids research, 2009-02, Vol.37 (3), p.661-671</ispartof><rights>2009 The Author(s) 2009</rights><rights>2009 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-b0a06a4bd2d46724d8ce76fec9ad73f294f9cd96f27761221495329c4b533c373</citedby><cites>FETCH-LOGICAL-c526t-b0a06a4bd2d46724d8ce76fec9ad73f294f9cd96f27761221495329c4b533c373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647305/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647305/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1598,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19240147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Zhirong</creatorcontrib><creatorcontrib>Deibler, Richard W</creatorcontrib><creatorcontrib>Chan, Hue Sun</creatorcontrib><creatorcontrib>Zechiedrich, Lynn</creatorcontrib><title>why and how of DNA unlinking</title><title>Nucleic acids research</title><addtitle>Nucleic Acids Res</addtitle><description>The nucleotide sequence of DNA is the repository of hereditary information. 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We close with a discussion on recent theoretical advances indicating that the topological problems, themselves, can provide the cues necessary for their resolution by type-2 topoisomerases.</description><subject>DNA - chemistry</subject><subject>DNA - metabolism</subject><subject>DNA Topoisomerases, Type II - metabolism</subject><subject>Models, Molecular</subject><subject>Nucleic Acid Conformation</subject><subject>Survey and Summary</subject><issn>0305-1048</issn><issn>1362-4962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNqF0UlLxDAABeAgio7LxbNoEfQgVLM1aS6CuIso4oJ4CZk0nanTScZk6vLvjXRwO-gphHx5WR4AywhuIyjIjlV-pzcYQYqmQAcRhlMqGJ4GHUhgliJI8zkwH8IjhIiijM6COSQwjRPeASsv_bdE2SLpu5fElcnBxV7S2Lqyg8r2FsFMqepglibjArg9OrzZP0nPL49P9_fOU51hNk67UEGmaLfABWUc0yLXhrPSaKEKTkosaCl0IViJOWcIY0RFRrDQtJsRogknC2C3zR013aEptLFjr2o58tVQ-TfpVCV_rtiqL3vuWWJGeXxjDNicBHj31JgwlsMqaFPXyhrXBMmYYJTE0_6DGGKEYJ5HuP4LPrrG2_gL0UCWE5LRiLZapL0LwZvy88oIyo9qZKxGttVEvPr9kV900kUEGy1wzejvoLR1VRib10-p_EAyTngmT-4f5NXN3dn9BeMSR7_W-lI5qXq-CvL2GkNEIMpEnsc97-HTrO8</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Liu, Zhirong</creator><creator>Deibler, Richard W</creator><creator>Chan, Hue Sun</creator><creator>Zechiedrich, Lynn</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>FBQ</scope><scope>BSCLL</scope><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090201</creationdate><title>why and how of DNA unlinking</title><author>Liu, Zhirong ; 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| ispartof | Nucleic acids research, 2009-02, Vol.37 (3), p.661-671 |
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| language | eng |
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| source | Oxford Journals Open Access Collection; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | DNA - chemistry DNA - metabolism DNA Topoisomerases, Type II - metabolism Models, Molecular Nucleic Acid Conformation Survey and Summary |
| title | why and how of DNA unlinking |
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