CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

Cytotoxic T lymphocyte antigen-4 (CTLA-4) plays a critical role in negatively regulating T cell responses and has also been implicated in the development and function of natural FOXP3(+) regulatory T cells. CTLA-4-deficient mice develop fatal, early onset lymphoproliferative disease. However, chimer...

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Veröffentlicht in:	The Journal of experimental medicine 2009-02, Vol.206 (2), p.421-434
Hauptverfasser:	Friedline, Randall H, Brown, David S, Nguyen, Hai, Kornfeld, Hardy, Lee, Jinhee, Zhang, Yi, Appleby, Mark, Der, Sandy D, Kang, Joonsoo, Chambers, Cynthia A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antigens, CD - genetics Antigens, CD - immunology Bromodeoxyuridine CTLA-4 Antigen DNA Primers - genetics Flow Cytometry Forkhead Transcription Factors - immunology Gene Expression Regulation - immunology Mice Mice, Knockout Reverse Transcriptase Polymerase Chain Reaction Self Tolerance - immunology T-Lymphocytes, Regulatory - immunology
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