Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly

In animal somatic cells, bipolar spindle formation requires separation of the centrosome-based spindle poles. Centrosome separation relies on multiple pathways, including cortical forces and antiparallel microtubule (MT) sliding, which are two activities controlled by the protein kinase aurora A. We...

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Veröffentlicht in:	The Journal of cell biology 2009-02, Vol.184 (3), p.365-372
Hauptverfasser:	Toso, Alberto, Winter, Jennifer R, Garrod, Ainslie J, Amaro, Ana C, Meraldi, Patrick, McAinsh, Andrew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aurora Kinases Auroras Biochemistry Cell Cycle - physiology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cells Centrosome - metabolism Centrosomes Chromosomes Epithelial cells Genetics HeLa Cells Humans Kinases Kinetochores Kinetochores - metabolism Microtubules Microtubules - metabolism Mitotic spindle apparatus Prophase Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Somatic cells Spindle Apparatus - metabolism Stress, Mechanical
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