Insig Regulates HMG-CoA Reductase by Controlling Enzyme Phosphorylation in Fission Yeast

Insig functions as a central regulator of cellular cholesterol homeostasis by controlling activity of HMG-CoA reductase (HMGR) in cholesterol synthesis. Insig both accelerates the degradation of HMGR and suppresses HMGR transcription through the SREBP-Scap pathway. The fission yeast Schizosaccharomy...

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Veröffentlicht in:	Cell metabolism 2008-12, Vol.8 (6), p.522-531
Hauptverfasser:	Burg, John S., Powell, David W., Chai, Raymond, Hughes, Adam L., Link, Andrew J., Espenshade, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Hydroxymethylglutaryl CoA Reductases - biosynthesis Hydroxymethylglutaryl CoA Reductases - metabolism Immunoprecipitation Intracellular Signaling Peptides and Proteins - metabolism MAP Kinase Kinase 1 - metabolism Membrane Proteins - metabolism Membrane Proteins - physiology Mitogen-Activated Protein Kinases - metabolism Molecular Sequence Data Phosphorylation Schizosaccharomyces - enzymology Schizosaccharomyces - growth & development Schizosaccharomyces pombe Proteins - metabolism Schizosaccharomyces pombe Proteins - physiology SIGNALING Stress, Physiological
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