Influence of age on inducibility and cholinergic modulation of arrhythmia in isolated rat right atria
The effects of carbachol and atropine on the number of trains (NT) and on the train stimulus strength (SS) necessary to induce arrhythmia were studied in isolated right atria of infant, young, adult and mature rats submitted to electric field stimulation (66.7 Hz, 5 ms pulse-duration, 250 pulses). C...
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| Veröffentlicht in: | AGE 2009-03, Vol.31 (1), p.51-58 |
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| creator | Faria, D. M Viviane, A. G Galvão, K. M Caricati-Neto, A Godoy, C. M. G |
| description | The effects of carbachol and atropine on the number of trains (NT) and on the train stimulus strength (SS) necessary to induce arrhythmia were studied in isolated right atria of infant, young, adult and mature rats submitted to electric field stimulation (66.7 Hz, 5 ms pulse-duration, 250 pulses). Carbachol (1 μM) decreased NT from four (control) to two in all ages tested. Atropine (1 μM) prevented tachyarrhythmia induction in tissue of all ages, even with NT equal to 12, except for mature rats (typically four trains). The SS decreases from infant to adult age [5- to 2-fold atrial threshold (AT)] and increases in mature animals (5-fold AT). Carbachol changes this result only for mature rats (5- to 2-fold AT). The SS was decreased by carbachol (1 μM) from 5- to 3-fold AT in mature rats, but atropine did not modify SS in this age. These results indicate that inducibility and cholinergic modulation of atrial tachyarrhythmia is influenced by age. |
| doi_str_mv | 10.1007/s11357-008-9080-1 |
| format | Article |
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M ; Viviane, A. G ; Galvão, K. M ; Caricati-Neto, A ; Godoy, C. M. G</creator><creatorcontrib>Faria, D. M ; Viviane, A. G ; Galvão, K. M ; Caricati-Neto, A ; Godoy, C. M. G</creatorcontrib><description>The effects of carbachol and atropine on the number of trains (NT) and on the train stimulus strength (SS) necessary to induce arrhythmia were studied in isolated right atria of infant, young, adult and mature rats submitted to electric field stimulation (66.7 Hz, 5 ms pulse-duration, 250 pulses). Carbachol (1 μM) decreased NT from four (control) to two in all ages tested. Atropine (1 μM) prevented tachyarrhythmia induction in tissue of all ages, even with NT equal to 12, except for mature rats (typically four trains). The SS decreases from infant to adult age [5- to 2-fold atrial threshold (AT)] and increases in mature animals (5-fold AT). Carbachol changes this result only for mature rats (5- to 2-fold AT). The SS was decreased by carbachol (1 μM) from 5- to 3-fold AT in mature rats, but atropine did not modify SS in this age. These results indicate that inducibility and cholinergic modulation of atrial tachyarrhythmia is influenced by age.</description><identifier>ISSN: 0161-9152</identifier><identifier>ISSN: 2509-2715</identifier><identifier>EISSN: 2331-3765</identifier><identifier>EISSN: 1574-4647</identifier><identifier>EISSN: 2509-2723</identifier><identifier>DOI: 10.1007/s11357-008-9080-1</identifier><identifier>PMID: 19234768</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : Springer Netherlands</publisher><subject>Acetylcholine receptor ; age ; arrhythmia ; Biomedical and Life Sciences ; Cardiac arrhythmia ; Cell Biology ; Cholinergic ; Geriatrics/Gerontology ; Life Sciences ; Molecular Medicine ; myocardium ; Rodents</subject><ispartof>AGE, 2009-03, Vol.31 (1), p.51-58</ispartof><rights>American Aging Association, Media, PA, USA 2008</rights><rights>American Aging Association, Media, PA, USA 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-d744e637ffb6647f8d7cd69838ea7c486961d65e5b5a850bfb49f2eb3787badc3</citedby><cites>FETCH-LOGICAL-c558t-d744e637ffb6647f8d7cd69838ea7c486961d65e5b5a850bfb49f2eb3787badc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645994/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645994/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19234768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faria, D. M</creatorcontrib><creatorcontrib>Viviane, A. G</creatorcontrib><creatorcontrib>Galvão, K. M</creatorcontrib><creatorcontrib>Caricati-Neto, A</creatorcontrib><creatorcontrib>Godoy, C. M. G</creatorcontrib><title>Influence of age on inducibility and cholinergic modulation of arrhythmia in isolated rat right atria</title><title>AGE</title><addtitle>AGE</addtitle><addtitle>Age (Dordr)</addtitle><description>The effects of carbachol and atropine on the number of trains (NT) and on the train stimulus strength (SS) necessary to induce arrhythmia were studied in isolated right atria of infant, young, adult and mature rats submitted to electric field stimulation (66.7 Hz, 5 ms pulse-duration, 250 pulses). Carbachol (1 μM) decreased NT from four (control) to two in all ages tested. Atropine (1 μM) prevented tachyarrhythmia induction in tissue of all ages, even with NT equal to 12, except for mature rats (typically four trains). The SS decreases from infant to adult age [5- to 2-fold atrial threshold (AT)] and increases in mature animals (5-fold AT). Carbachol changes this result only for mature rats (5- to 2-fold AT). The SS was decreased by carbachol (1 μM) from 5- to 3-fold AT in mature rats, but atropine did not modify SS in this age. These results indicate that inducibility and cholinergic modulation of atrial tachyarrhythmia is influenced by age.</description><subject>Acetylcholine receptor</subject><subject>age</subject><subject>arrhythmia</subject><subject>Biomedical and Life Sciences</subject><subject>Cardiac arrhythmia</subject><subject>Cell Biology</subject><subject>Cholinergic</subject><subject>Geriatrics/Gerontology</subject><subject>Life Sciences</subject><subject>Molecular Medicine</subject><subject>myocardium</subject><subject>Rodents</subject><issn>0161-9152</issn><issn>2509-2715</issn><issn>2331-3765</issn><issn>1574-4647</issn><issn>2509-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtv1DAcxCMEokvhA3ABi0tPAb8fF6Sq4lGpEgfo2XL8SFxl7WInlfbb41VWFDhw-h_mN2OPputeI_geQSg-VIQIEz2EsldQwh496XaYENQTwdnTbgcRR71CDJ91L2q9g5BATMXz7gwpTKjgctf56xTm1SfrQQ7AjO0kEJNbbRziHJcDMMkBO-U5Jl_GaME-u3U2S2zc0VHKdFimfTTNBWLNTfIOFLOAEsdpAWYp0bzsngUzV__qdM-728-fflx97W--fbm-urzpLWNy6Z2g1HMiQhg4pyJIJ6zjShLpjbBUcsWR48yzgRnJ4BAGqgL2AxFSDMZZct593HLv12HvnfVpKWbW9yXuTTnobKL-W0lx0mN-0JhTphRtARengJJ_rr4ueh-r9fNsks9r1YIQqRTmpJHv_iHv8lpSa6elUJS1RNEgtEG25FqLD7-_gqA-Tqi3CXWbUB8n1Kh53vzZ4dFx2qwBeANqk9Loy-PL_0t9u5mCydqMJVZ9-x1DRCBqxTFS5BddI7JE</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Faria, D. M</creator><creator>Viviane, A. G</creator><creator>Galvão, K. M</creator><creator>Caricati-Neto, A</creator><creator>Godoy, C. M. 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M</au><au>Viviane, A. G</au><au>Galvão, K. M</au><au>Caricati-Neto, A</au><au>Godoy, C. M. G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of age on inducibility and cholinergic modulation of arrhythmia in isolated rat right atria</atitle><jtitle>AGE</jtitle><stitle>AGE</stitle><addtitle>Age (Dordr)</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>31</volume><issue>1</issue><spage>51</spage><epage>58</epage><pages>51-58</pages><issn>0161-9152</issn><issn>2509-2715</issn><eissn>2331-3765</eissn><eissn>1574-4647</eissn><eissn>2509-2723</eissn><abstract>The effects of carbachol and atropine on the number of trains (NT) and on the train stimulus strength (SS) necessary to induce arrhythmia were studied in isolated right atria of infant, young, adult and mature rats submitted to electric field stimulation (66.7 Hz, 5 ms pulse-duration, 250 pulses). Carbachol (1 μM) decreased NT from four (control) to two in all ages tested. Atropine (1 μM) prevented tachyarrhythmia induction in tissue of all ages, even with NT equal to 12, except for mature rats (typically four trains). The SS decreases from infant to adult age [5- to 2-fold atrial threshold (AT)] and increases in mature animals (5-fold AT). Carbachol changes this result only for mature rats (5- to 2-fold AT). The SS was decreased by carbachol (1 μM) from 5- to 3-fold AT in mature rats, but atropine did not modify SS in this age. These results indicate that inducibility and cholinergic modulation of atrial tachyarrhythmia is influenced by age.</abstract><cop>Dordrecht</cop><pub>Dordrecht : Springer Netherlands</pub><pmid>19234768</pmid><doi>10.1007/s11357-008-9080-1</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylcholine receptor age arrhythmia Biomedical and Life Sciences Cardiac arrhythmia Cell Biology Cholinergic Geriatrics/Gerontology Life Sciences Molecular Medicine myocardium Rodents |
| title | Influence of age on inducibility and cholinergic modulation of arrhythmia in isolated rat right atria |
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