Association Between Vitamin D Status and Physical Performance: The InCHIANTI Study
Background. Vitamin D status has been hypothesized to play a role in musculoskeletal function. Using data from the InCHIANTI study, we examined the association between vitamin D status and physical performance. Methods. A representative sample of 976 persons aged 65 years or older at study baseline...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2007-04, Vol.62 (4), p.440-446 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Houston, Denise K. Cesari, Matteo Ferrucci, Luigi Cherubini, Antonio Maggio, Dario Bartali, Benedetta Johnson, Mary Ann Schwartz, Gary G. Kritchevsky, Stephen B. |
| description | Background. Vitamin D status has been hypothesized to play a role in musculoskeletal function. Using data from the InCHIANTI study, we examined the association between vitamin D status and physical performance. Methods. A representative sample of 976 persons aged 65 years or older at study baseline were included. Physical performance was assessed using a short physical performance battery (SPPB) and handgrip strength. Multiple linear regression was used to examine the association between vitamin D (serum 25OHD), parathyroid hormone (PTH), and physical performance adjusting for sociodemographic variables, behavioral characteristics, body mass index, season, cognition, health conditions, creatinine, hemoglobin, and albumin. Results. Approximately 28.8% of women and 13.6% of men had vitamin D levels indicative of deficiency (serum 25OHD < 25.0 nmol/L) and 74.9% of women and 51.0% of men had vitamin D levels indicative of vitamin D insufficiency (serum 25OHD < 50.0 nmol/L). Vitamin D levels were significantly associated with SPPB score in men (β coefficient [standard error (SE)]: 0.38 [0.18], p =.04) and handgrip strength in men (2.44 [0.84], p =.004) and women (1.33 [0.53], p =.01). Men and women with serum 25OHD < 25.0 nmol/L had significantly lower SPPB scores whereas those with serum 25OHD < 50 nmol/L had significantly lower handgrip strength than those with serum 25OHD ≥25 and ≥50 nmol/L, respectively (p |
| doi_str_mv | 10.1093/gerona/62.4.440 |
| format | Article |
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Vitamin D status has been hypothesized to play a role in musculoskeletal function. Using data from the InCHIANTI study, we examined the association between vitamin D status and physical performance. Methods. A representative sample of 976 persons aged 65 years or older at study baseline were included. Physical performance was assessed using a short physical performance battery (SPPB) and handgrip strength. Multiple linear regression was used to examine the association between vitamin D (serum 25OHD), parathyroid hormone (PTH), and physical performance adjusting for sociodemographic variables, behavioral characteristics, body mass index, season, cognition, health conditions, creatinine, hemoglobin, and albumin. Results. Approximately 28.8% of women and 13.6% of men had vitamin D levels indicative of deficiency (serum 25OHD < 25.0 nmol/L) and 74.9% of women and 51.0% of men had vitamin D levels indicative of vitamin D insufficiency (serum 25OHD < 50.0 nmol/L). Vitamin D levels were significantly associated with SPPB score in men (β coefficient [standard error (SE)]: 0.38 [0.18], p =.04) and handgrip strength in men (2.44 [0.84], p =.004) and women (1.33 [0.53], p =.01). Men and women with serum 25OHD < 25.0 nmol/L had significantly lower SPPB scores whereas those with serum 25OHD < 50 nmol/L had significantly lower handgrip strength than those with serum 25OHD ≥25 and ≥50 nmol/L, respectively (p <.05). PTH was significantly associated with handgrip strength only (p =.01). Conclusions. Vitamin D status was inversely associated with poor physical performance. Given the high prevalence of vitamin D deficiency in older populations, additional studies examining the association between vitamin D status and physical function are needed.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/62.4.440</identifier><identifier>PMID: 17452740</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aged ; Bone density ; Cross-Sectional Studies ; Female ; Hand Strength ; Humans ; Incidence ; Male ; Nutrition ; Older people ; Parathyroid Hormone - blood ; Physical Fitness ; Sex Distribution ; Sex Factors ; Studies ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - epidemiology ; Vitamin D Deficiency - physiopathology</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2007-04, Vol.62 (4), p.440-446</ispartof><rights>Copyright Gerontological Society of America, Incorporated Apr 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-4b1c072f8150a93441480d52a304dee589b555c9f730c469aa28c934670eb44b3</citedby><cites>FETCH-LOGICAL-c522t-4b1c072f8150a93441480d52a304dee589b555c9f730c469aa28c934670eb44b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17452740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Houston, Denise K.</creatorcontrib><creatorcontrib>Cesari, Matteo</creatorcontrib><creatorcontrib>Ferrucci, Luigi</creatorcontrib><creatorcontrib>Cherubini, Antonio</creatorcontrib><creatorcontrib>Maggio, Dario</creatorcontrib><creatorcontrib>Bartali, Benedetta</creatorcontrib><creatorcontrib>Johnson, Mary Ann</creatorcontrib><creatorcontrib>Schwartz, Gary G.</creatorcontrib><creatorcontrib>Kritchevsky, Stephen B.</creatorcontrib><title>Association Between Vitamin D Status and Physical Performance: The InCHIANTI Study</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Background. Vitamin D status has been hypothesized to play a role in musculoskeletal function. Using data from the InCHIANTI study, we examined the association between vitamin D status and physical performance. Methods. A representative sample of 976 persons aged 65 years or older at study baseline were included. Physical performance was assessed using a short physical performance battery (SPPB) and handgrip strength. Multiple linear regression was used to examine the association between vitamin D (serum 25OHD), parathyroid hormone (PTH), and physical performance adjusting for sociodemographic variables, behavioral characteristics, body mass index, season, cognition, health conditions, creatinine, hemoglobin, and albumin. Results. Approximately 28.8% of women and 13.6% of men had vitamin D levels indicative of deficiency (serum 25OHD < 25.0 nmol/L) and 74.9% of women and 51.0% of men had vitamin D levels indicative of vitamin D insufficiency (serum 25OHD < 50.0 nmol/L). Vitamin D levels were significantly associated with SPPB score in men (β coefficient [standard error (SE)]: 0.38 [0.18], p =.04) and handgrip strength in men (2.44 [0.84], p =.004) and women (1.33 [0.53], p =.01). Men and women with serum 25OHD < 25.0 nmol/L had significantly lower SPPB scores whereas those with serum 25OHD < 50 nmol/L had significantly lower handgrip strength than those with serum 25OHD ≥25 and ≥50 nmol/L, respectively (p <.05). PTH was significantly associated with handgrip strength only (p =.01). Conclusions. Vitamin D status was inversely associated with poor physical performance. Given the high prevalence of vitamin D deficiency in older populations, additional studies examining the association between vitamin D status and physical function are needed.</description><subject>Aged</subject><subject>Bone density</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Hand Strength</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Nutrition</subject><subject>Older people</subject><subject>Parathyroid Hormone - blood</subject><subject>Physical Fitness</subject><subject>Sex Distribution</subject><subject>Sex Factors</subject><subject>Studies</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin D Deficiency - physiopathology</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctvEzEQxi0EoqVw5oYsDtw2sb1-7HJASsMjKRWUEKqKi-X1ehuXXbvYXiD_PY4SlcdcZqT5zaeZ-QB4itEEo7qcXpvgnZpyMqETStE9cIwFqwpWsqv7uUaiLhhC_Ag8ivEG7YKRh-AIC8qIoOgYrGYxem1Vst7BU5N-GuPgpU1qsA6-hp-TSmOEyrXwYrONVqseXpjQ-TAop81LuN4YuHTzxXL2Yb3M-NhuH4MHneqjeXLIJ-DL2zfr-aI4__huOZ-dF5oRkgraYI0E6SrMkKpLSjGtUMuIKhFtjWFV3TDGdN2JEmnKa6VIpTPHBTINpU15Al7tdW_HZjCtNi4F1cvbYAcVttIrK__tOLuR1_6HJJwyzkgWeHEQCP77aGKSg43a9L1yxo9RCkQJJmIHPv8PvPFjcPk4SVDFMcnPzNB0D-ngYwymu9sEI7kzS-7NkpxIKrNZeeLZ3wf84Q_uZKDYAzYm8-uur8I3yUUpmFxcfZWXZ59Wq9P3Z5KUvwFn2593</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Houston, Denise K.</creator><creator>Cesari, Matteo</creator><creator>Ferrucci, Luigi</creator><creator>Cherubini, Antonio</creator><creator>Maggio, Dario</creator><creator>Bartali, Benedetta</creator><creator>Johnson, Mary Ann</creator><creator>Schwartz, Gary G.</creator><creator>Kritchevsky, Stephen B.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070401</creationdate><title>Association Between Vitamin D Status and Physical Performance: The InCHIANTI Study</title><author>Houston, Denise K. ; Cesari, Matteo ; Ferrucci, Luigi ; Cherubini, Antonio ; Maggio, Dario ; Bartali, Benedetta ; Johnson, Mary Ann ; Schwartz, Gary G. ; Kritchevsky, Stephen B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-4b1c072f8150a93441480d52a304dee589b555c9f730c469aa28c934670eb44b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Bone density</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Hand Strength</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Nutrition</topic><topic>Older people</topic><topic>Parathyroid Hormone - blood</topic><topic>Physical Fitness</topic><topic>Sex Distribution</topic><topic>Sex Factors</topic><topic>Studies</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin D Deficiency - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Houston, Denise K.</creatorcontrib><creatorcontrib>Cesari, Matteo</creatorcontrib><creatorcontrib>Ferrucci, Luigi</creatorcontrib><creatorcontrib>Cherubini, Antonio</creatorcontrib><creatorcontrib>Maggio, Dario</creatorcontrib><creatorcontrib>Bartali, Benedetta</creatorcontrib><creatorcontrib>Johnson, Mary Ann</creatorcontrib><creatorcontrib>Schwartz, Gary G.</creatorcontrib><creatorcontrib>Kritchevsky, Stephen B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Houston, Denise K.</au><au>Cesari, Matteo</au><au>Ferrucci, Luigi</au><au>Cherubini, Antonio</au><au>Maggio, Dario</au><au>Bartali, Benedetta</au><au>Johnson, Mary Ann</au><au>Schwartz, Gary G.</au><au>Kritchevsky, Stephen B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Vitamin D Status and Physical Performance: The InCHIANTI Study</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>62</volume><issue>4</issue><spage>440</spage><epage>446</epage><pages>440-446</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Background. Vitamin D status has been hypothesized to play a role in musculoskeletal function. Using data from the InCHIANTI study, we examined the association between vitamin D status and physical performance. Methods. A representative sample of 976 persons aged 65 years or older at study baseline were included. Physical performance was assessed using a short physical performance battery (SPPB) and handgrip strength. Multiple linear regression was used to examine the association between vitamin D (serum 25OHD), parathyroid hormone (PTH), and physical performance adjusting for sociodemographic variables, behavioral characteristics, body mass index, season, cognition, health conditions, creatinine, hemoglobin, and albumin. Results. Approximately 28.8% of women and 13.6% of men had vitamin D levels indicative of deficiency (serum 25OHD < 25.0 nmol/L) and 74.9% of women and 51.0% of men had vitamin D levels indicative of vitamin D insufficiency (serum 25OHD < 50.0 nmol/L). Vitamin D levels were significantly associated with SPPB score in men (β coefficient [standard error (SE)]: 0.38 [0.18], p =.04) and handgrip strength in men (2.44 [0.84], p =.004) and women (1.33 [0.53], p =.01). Men and women with serum 25OHD < 25.0 nmol/L had significantly lower SPPB scores whereas those with serum 25OHD < 50 nmol/L had significantly lower handgrip strength than those with serum 25OHD ≥25 and ≥50 nmol/L, respectively (p <.05). PTH was significantly associated with handgrip strength only (p =.01). Conclusions. Vitamin D status was inversely associated with poor physical performance. Given the high prevalence of vitamin D deficiency in older populations, additional studies examining the association between vitamin D status and physical function are needed.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>17452740</pmid><doi>10.1093/gerona/62.4.440</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 2007-04, Vol.62 (4), p.440-446 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Aged Bone density Cross-Sectional Studies Female Hand Strength Humans Incidence Male Nutrition Older people Parathyroid Hormone - blood Physical Fitness Sex Distribution Sex Factors Studies Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - epidemiology Vitamin D Deficiency - physiopathology |
| title | Association Between Vitamin D Status and Physical Performance: The InCHIANTI Study |
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