Probing the pH-Dependent Prepore to Pore Transition of Bacillus anthracis Protective Antigen with Differential Oxidative Protein Footprinting

The protective antigen (PA) component of the anthrax toxin (ATx) plays an essential role in the pathogenesis of the bioterrorism bacterium Bacillus anthracis. After oligomerization on the cell surface and docking of lethal factor and/or edema factor, PA is internalized and undergoes a conformational...

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Veröffentlicht in:	Biochemistry (Easton) 2008-10, Vol.47 (40), p.10694-10704
Hauptverfasser:	Smedley, James G, Sharp, Joshua S, Kuhn, Jeffrey F, Tomer, Kenneth B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigens, Bacterial - chemistry Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Bacillus anthracis - genetics Bacillus anthracis - metabolism Bacterial Toxins - chemistry Bacterial Toxins - genetics Bacterial Toxins - metabolism Chromatography, High Pressure Liquid Hydrogen-Ion Concentration Models, Molecular Molecular Sequence Data Oxidation-Reduction Protein Conformation Protein Footprinting - methods Protein Structure, Secondary Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry
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