Antioxidant properties of MitoTEMPOL and its hydroxylamine

Piperidine nitroxides such as TEMPOL have been widely used as antioxidants in vitro and in vivo. MitoTEMPOL is a mitochondria-targeted derivative of TEMPOL designed to protect mitochondria from the oxidative damage that they accumulate, but once there is rapidly reduced to its hydroxylamine, MitoTEM...

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Veröffentlicht in:	Free radical research 2009-01, Vol.43 (1), p.4-12
Hauptverfasser:	Trnka, Jan, Blaikie, Frances H., Logan, Angela, Smith, Robin A. J., Murphy, Michael P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antioxidant Antioxidants - pharmacology Cyclic N-Oxides - pharmacology DNA, Mitochondrial - drug effects hydroxylamine Hydroxylamine - pharmacology lipid peroxidation Lipid Peroxidation - drug effects Mice Mitochondria, Liver - drug effects MitoTEMPOL mtDNA nitroxide Oxidation-Reduction - drug effects Polymerase Chain Reaction Rats Spin Labels Superoxide Dismutase - metabolism
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