Striatal 5-HT1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat

Convergent evidence suggests that serotonin 5-HT1A receptor (5-HT1AR) agonists reduce l-DOPA-induced dyskinesia by auto-regulating aberrant release of l-DOPA-derived dopamine (DA) from raphestriatal neurons. However, recent findings indicate that 5-HT1AR stimulation also modifies D1 receptor (D1R)-m...

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Veröffentlicht in:	Neuropharmacology 2008-12, Vol.55 (8), p.1321-1328
Hauptverfasser:	Dupre, Kristin B., Eskow, Karen L., Barnum, Christopher J., Bishop, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT1A receptor 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Adrenergic Agents - toxicity Animals Benzazepines - pharmacology Biogenic Monoamines - metabolism Brain Chemistry - drug effects Chromatography, High Pressure Liquid - methods Corpus Striatum - drug effects Corpus Striatum - metabolism D1 receptor Desipramine - pharmacology Disease Models, Animal Dopamine Dopamine Agonists - pharmacology Dyskinesia Dyskinesia, Drug-Induced - metabolism Enzyme Inhibitors - pharmacology Functional Laterality - drug effects Functional Laterality - physiology l-DOPA Male Movement Disorders - drug therapy Movement Disorders - etiology Movement Disorders - metabolism Oxidopamine - toxicity Parkinson Disease - complications Parkinson Disease - drug therapy Parkinson Disease - pathology Parkinson's disease Piperazines - pharmacology Psychomotor Performance - drug effects Pyridines - pharmacology Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT1A - metabolism Receptors, Dopamine D1 - metabolism Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology Time Factors
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