A genetic contribution to circulating cytokines and obesity in children
Cytokines are considered to be involved in obesity-related metabolic diseases. Study objectives are to determine the heritability of circulating cytokine levels, to investigate pleiotropy between cytokines and obesity traits, and to present genome scan results for cytokines in 1030 Hispanic children...
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| Veröffentlicht in: | Cytokine (Philadelphia, Pa.) Pa.), 2008-11, Vol.44 (2), p.242-247 |
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| container_title | Cytokine (Philadelphia, Pa.) |
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| creator | Cai, Guowen Cole, Shelley A. Butte, Nancy F. Smith, C. Wayne Mehta, Nitesh R. Voruganti, V. Saroja Proffitt, J. Michael Comuzzie, Anthony G. |
| description | Cytokines are considered to be involved in obesity-related metabolic diseases. Study objectives are to determine the heritability of circulating cytokine levels, to investigate pleiotropy between cytokines and obesity traits, and to present genome scan results for cytokines in 1030 Hispanic children enrolled in VIVA LA FAMILIA Study. Cytokine phenotypes included monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), transforming growth factor beta 1 (TGF-β1), C-reactive protein (CRP), regulated upon activation, normal T-cell expressed and secreted (RANTES) and eotaxin. Obesity-related phenotypes included body mass index (BMI), fat mass (FM), truncal FM and fasting serum insulin. Heritabilities ranged from 0.33 to 0.97. Pleiotropy was observed between cytokines and obesity traits. Positive genetic correlations were seen between CRP, leptin, MCP-1 and obesity traits, and negative genetic correlations with adiponectin, ICAM-1 and TGF-β1. Genome-wide scan of sICAM-1 mapped to chromosome 3 (LOD
=
3.74) between markers
D3S1580 and
D3S1601, which flanks the adiponectin gene (
ADIPOQ). Suggestive linkage signals were found in other chromosomal regions for other cytokines. In summary, significant heritabilities for circulating cytokines, pleiotropy between cytokines and obesity traits, and linkage for sICAM-1 on chromosome 3q substantiate a genetic contribution to circulating cytokine levels in Hispanic children. |
| doi_str_mv | 10.1016/j.cyto.2008.08.006 |
| format | Article |
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=
3.74) between markers
D3S1580 and
D3S1601, which flanks the adiponectin gene (
ADIPOQ). Suggestive linkage signals were found in other chromosomal regions for other cytokines. In summary, significant heritabilities for circulating cytokines, pleiotropy between cytokines and obesity traits, and linkage for sICAM-1 on chromosome 3q substantiate a genetic contribution to circulating cytokine levels in Hispanic children.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2008.08.006</identifier><identifier>PMID: 18848781</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Animals ; Anthropometry ; Body Composition - genetics ; Body Mass Index ; Child ; Child, Preschool ; Childhood obesity ; Cytokines ; Cytokines - blood ; Cytokines - genetics ; Cytokines - immunology ; Genetic Predisposition to Disease ; Genome-wide scan ; Genotype ; Hispanic Americans - genetics ; Humans ; Inflammation ; Obesity - blood ; Obesity - genetics ; Obesity - immunology ; Phenotype ; Young Adult</subject><ispartof>Cytokine (Philadelphia, Pa.), 2008-11, Vol.44 (2), p.242-247</ispartof><rights>2008 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-118760d5ca91f3211aab06283a4b5af788d02d8d4e2f5a18f6e864899a803cca3</citedby><cites>FETCH-LOGICAL-c484t-118760d5ca91f3211aab06283a4b5af788d02d8d4e2f5a18f6e864899a803cca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cyto.2008.08.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18848781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Guowen</creatorcontrib><creatorcontrib>Cole, Shelley A.</creatorcontrib><creatorcontrib>Butte, Nancy F.</creatorcontrib><creatorcontrib>Smith, C. Wayne</creatorcontrib><creatorcontrib>Mehta, Nitesh R.</creatorcontrib><creatorcontrib>Voruganti, V. Saroja</creatorcontrib><creatorcontrib>Proffitt, J. Michael</creatorcontrib><creatorcontrib>Comuzzie, Anthony G.</creatorcontrib><title>A genetic contribution to circulating cytokines and obesity in children</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>Cytokines are considered to be involved in obesity-related metabolic diseases. Study objectives are to determine the heritability of circulating cytokine levels, to investigate pleiotropy between cytokines and obesity traits, and to present genome scan results for cytokines in 1030 Hispanic children enrolled in VIVA LA FAMILIA Study. Cytokine phenotypes included monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), transforming growth factor beta 1 (TGF-β1), C-reactive protein (CRP), regulated upon activation, normal T-cell expressed and secreted (RANTES) and eotaxin. Obesity-related phenotypes included body mass index (BMI), fat mass (FM), truncal FM and fasting serum insulin. Heritabilities ranged from 0.33 to 0.97. Pleiotropy was observed between cytokines and obesity traits. Positive genetic correlations were seen between CRP, leptin, MCP-1 and obesity traits, and negative genetic correlations with adiponectin, ICAM-1 and TGF-β1. Genome-wide scan of sICAM-1 mapped to chromosome 3 (LOD
=
3.74) between markers
D3S1580 and
D3S1601, which flanks the adiponectin gene (
ADIPOQ). Suggestive linkage signals were found in other chromosomal regions for other cytokines. In summary, significant heritabilities for circulating cytokines, pleiotropy between cytokines and obesity traits, and linkage for sICAM-1 on chromosome 3q substantiate a genetic contribution to circulating cytokine levels in Hispanic children.</description><subject>Adolescent</subject><subject>Animals</subject><subject>Anthropometry</subject><subject>Body Composition - genetics</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood obesity</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Cytokines - genetics</subject><subject>Cytokines - immunology</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-wide scan</subject><subject>Genotype</subject><subject>Hispanic Americans - genetics</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Obesity - blood</subject><subject>Obesity - genetics</subject><subject>Obesity - immunology</subject><subject>Phenotype</subject><subject>Young Adult</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpadK0f6CHolNv3o5sWZahFEJI0kKgl_YsZGm8ma1XSiU5sP8-Nrv049LCwAzomXdG8zL2VsBGgFAfdht3KHFTA-jNGqCesXMBvaoA6ub5WsumkkqpM_Yq5x0A9E3XvWRnQmupOy3O2e0l32LAQo67GEqiYS4UAy-RO0punmyhsOXroB8UMHMbPI8DZioHToG7e5p8wvCavRjtlPHNKV-w7zfX364-V3dfb79cXd5VTmpZKiF0p8C3zvZibGohrB1A1bqxcmjt2GntofbaS6zH1go9KtRK6r63GhrnbHPBPh11H-Zhj97hsrOdzEOivU0HEy2Zv18C3ZttfDS1knKZswi8Pwmk-HPGXMyessNpsgHjnI3qux7aTvwXFH0n2kbAAtZH0KWYc8Lx1zYCzGqU2Zn1fmY1yqwBaml69-c_frecnFmAj0cAl2s-EiaTHWFw6CmhK8ZH-pf-E3DbphU</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Cai, Guowen</creator><creator>Cole, Shelley A.</creator><creator>Butte, Nancy F.</creator><creator>Smith, C. Wayne</creator><creator>Mehta, Nitesh R.</creator><creator>Voruganti, V. Saroja</creator><creator>Proffitt, J. Michael</creator><creator>Comuzzie, Anthony G.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081101</creationdate><title>A genetic contribution to circulating cytokines and obesity in children</title><author>Cai, Guowen ; Cole, Shelley A. ; Butte, Nancy F. ; Smith, C. Wayne ; Mehta, Nitesh R. ; Voruganti, V. Saroja ; Proffitt, J. Michael ; Comuzzie, Anthony G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-118760d5ca91f3211aab06283a4b5af788d02d8d4e2f5a18f6e864899a803cca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Animals</topic><topic>Anthropometry</topic><topic>Body Composition - genetics</topic><topic>Body Mass Index</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood obesity</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Cytokines - genetics</topic><topic>Cytokines - immunology</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome-wide scan</topic><topic>Genotype</topic><topic>Hispanic Americans - genetics</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Obesity - blood</topic><topic>Obesity - genetics</topic><topic>Obesity - immunology</topic><topic>Phenotype</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Guowen</creatorcontrib><creatorcontrib>Cole, Shelley A.</creatorcontrib><creatorcontrib>Butte, Nancy F.</creatorcontrib><creatorcontrib>Smith, C. Wayne</creatorcontrib><creatorcontrib>Mehta, Nitesh R.</creatorcontrib><creatorcontrib>Voruganti, V. Saroja</creatorcontrib><creatorcontrib>Proffitt, J. Michael</creatorcontrib><creatorcontrib>Comuzzie, Anthony G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Guowen</au><au>Cole, Shelley A.</au><au>Butte, Nancy F.</au><au>Smith, C. Wayne</au><au>Mehta, Nitesh R.</au><au>Voruganti, V. Saroja</au><au>Proffitt, J. Michael</au><au>Comuzzie, Anthony G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A genetic contribution to circulating cytokines and obesity in children</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>44</volume><issue>2</issue><spage>242</spage><epage>247</epage><pages>242-247</pages><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract>Cytokines are considered to be involved in obesity-related metabolic diseases. Study objectives are to determine the heritability of circulating cytokine levels, to investigate pleiotropy between cytokines and obesity traits, and to present genome scan results for cytokines in 1030 Hispanic children enrolled in VIVA LA FAMILIA Study. Cytokine phenotypes included monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), transforming growth factor beta 1 (TGF-β1), C-reactive protein (CRP), regulated upon activation, normal T-cell expressed and secreted (RANTES) and eotaxin. Obesity-related phenotypes included body mass index (BMI), fat mass (FM), truncal FM and fasting serum insulin. Heritabilities ranged from 0.33 to 0.97. Pleiotropy was observed between cytokines and obesity traits. Positive genetic correlations were seen between CRP, leptin, MCP-1 and obesity traits, and negative genetic correlations with adiponectin, ICAM-1 and TGF-β1. Genome-wide scan of sICAM-1 mapped to chromosome 3 (LOD
=
3.74) between markers
D3S1580 and
D3S1601, which flanks the adiponectin gene (
ADIPOQ). Suggestive linkage signals were found in other chromosomal regions for other cytokines. In summary, significant heritabilities for circulating cytokines, pleiotropy between cytokines and obesity traits, and linkage for sICAM-1 on chromosome 3q substantiate a genetic contribution to circulating cytokine levels in Hispanic children.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>18848781</pmid><doi>10.1016/j.cyto.2008.08.006</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cytokine (Philadelphia, Pa.), 2008-11, Vol.44 (2), p.242-247 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Animals Anthropometry Body Composition - genetics Body Mass Index Child Child, Preschool Childhood obesity Cytokines Cytokines - blood Cytokines - genetics Cytokines - immunology Genetic Predisposition to Disease Genome-wide scan Genotype Hispanic Americans - genetics Humans Inflammation Obesity - blood Obesity - genetics Obesity - immunology Phenotype Young Adult |
| title | A genetic contribution to circulating cytokines and obesity in children |
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