Activated TNF-α/NF-κB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice

The human CDKN2A locus encodes 2 distinct proteins, p16(INK4A) and p14(ARF) [mouse p19(Arf)], designated INK4A (inhibitor of cyclin dependent kinase 4) and ARF (alternative reading frame) here, that are translated from alternatively spliced mRNAs. Human ARF is implicated as a tumor suppressor gene,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-03, Vol.106 (9), p.3420-3425
Hauptverfasser:	Altomare, Deborah A, Menges, Craig W, Pei, Jianming, Zhang, Lili, Skele-Stump, Kristine L, Carbone, Michele, Kane, Agnes B, Testa, Joseph R
Format:	Artikel
Sprache:	eng
Schlagworte:	Asbestos Biological Sciences Cell cycle Cell lines Cell nucleus Cellular immunity Down regulation Mesothelioma Mice Tumor cell line Tumors
Online-Zugang:	Volltext
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