Aging white matter and cognition: Differential effects of regional variations in diffusion properties on memory, executive functions, and speed
Disruption of cerebral white matter has been proposed as an explanation for age-related cognitive declines. However, the role of specific regions in specific cognitive declines remains unclear. We used diffusion tensor imaging to examine the associations between regional microstructural integrity of...
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| Veröffentlicht in: | Neuropsychologia 2009-02, Vol.47 (3), p.916-927 |
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| creator | Kennedy, Kristen M. Raz, Naftali |
| description | Disruption of cerebral white matter has been proposed as an explanation for age-related cognitive declines. However, the role of specific regions in specific cognitive declines remains unclear. We used diffusion tensor imaging to examine the associations between regional microstructural integrity of the white matter and performance on age-sensitive cognitive tasks in a sample of healthy adults (
N
=
52, age 19–81 years). White matter integrity was assessed by fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in multiple regions of interest (genu and splenium of corpus callosum, internal capsule limbs, prefrontal, temporal, superior/posterior parietal, occipital white matter) and related to processing speed, working memory, inhibition, task switching, and episodic memory. We found that age and regional white matter integrity differentially influenced cognitive performance. Age-related degradation in anterior brain areas was associated with decreased processing speed and poorer working memory, whereas reduced inhibition and greater task switching costs were linked to decline in posterior areas. Poorer episodic memory was associated with age-related differences in central white matter regions. The observed multiple dissociations among specific age-sensitive cognitive skills and their putative neuroanatomical substrates support the view that age-related cognitive declines are unlikely to stem from a single cause. |
| doi_str_mv | 10.1016/j.neuropsychologia.2009.01.001 |
| format | Article |
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N
=
52, age 19–81 years). White matter integrity was assessed by fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in multiple regions of interest (genu and splenium of corpus callosum, internal capsule limbs, prefrontal, temporal, superior/posterior parietal, occipital white matter) and related to processing speed, working memory, inhibition, task switching, and episodic memory. We found that age and regional white matter integrity differentially influenced cognitive performance. Age-related degradation in anterior brain areas was associated with decreased processing speed and poorer working memory, whereas reduced inhibition and greater task switching costs were linked to decline in posterior areas. Poorer episodic memory was associated with age-related differences in central white matter regions. The observed multiple dissociations among specific age-sensitive cognitive skills and their putative neuroanatomical substrates support the view that age-related cognitive declines are unlikely to stem from a single cause.</description><identifier>ISSN: 0028-3932</identifier><identifier>EISSN: 1873-3514</identifier><identifier>DOI: 10.1016/j.neuropsychologia.2009.01.001</identifier><identifier>PMID: 19166865</identifier><identifier>CODEN: NUPSA6</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult ; Adult. Elderly ; Age Differences ; Age Factors ; Aged ; Aging ; Aging (Individuals) ; Biological and medical sciences ; Brain ; Brain - anatomy & histology ; Brain - physiology ; Brain Hemisphere Functions ; Cognition ; Cognition - physiology ; Cognitive Ability ; Cognitive Processes ; Corpus Callosum - physiology ; Developmental psychology ; Diffusion Magnetic Resonance Imaging ; Diffusion tensor imaging ; Disconnection ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Image Processing, Computer-Assisted ; Inhibition ; Inhibition (Psychology) ; Integrity ; Male ; Memory - physiology ; Middle Aged ; MRI ; Neurology ; Neuropsychological Tests ; Occipital Lobe - physiology ; Parietal Lobe - physiology ; Prefrontal Cortex - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychomotor Performance - physiology ; Short Term Memory ; Task Analysis ; Temporal Lobe - physiology ; White matter</subject><ispartof>Neuropsychologia, 2009-02, Vol.47 (3), p.916-927</ispartof><rights>2009 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c618t-4b4e06cb4ab357dd9b0dda3750d1d56fa97b4ca5d41f3a0a1884093051200e163</citedby><cites>FETCH-LOGICAL-c618t-4b4e06cb4ab357dd9b0dda3750d1d56fa97b4ca5d41f3a0a1884093051200e163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuropsychologia.2009.01.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ860690$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22046804$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19166865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kennedy, Kristen M.</creatorcontrib><creatorcontrib>Raz, Naftali</creatorcontrib><title>Aging white matter and cognition: Differential effects of regional variations in diffusion properties on memory, executive functions, and speed</title><title>Neuropsychologia</title><addtitle>Neuropsychologia</addtitle><description>Disruption of cerebral white matter has been proposed as an explanation for age-related cognitive declines. However, the role of specific regions in specific cognitive declines remains unclear. We used diffusion tensor imaging to examine the associations between regional microstructural integrity of the white matter and performance on age-sensitive cognitive tasks in a sample of healthy adults (
N
=
52, age 19–81 years). White matter integrity was assessed by fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in multiple regions of interest (genu and splenium of corpus callosum, internal capsule limbs, prefrontal, temporal, superior/posterior parietal, occipital white matter) and related to processing speed, working memory, inhibition, task switching, and episodic memory. We found that age and regional white matter integrity differentially influenced cognitive performance. Age-related degradation in anterior brain areas was associated with decreased processing speed and poorer working memory, whereas reduced inhibition and greater task switching costs were linked to decline in posterior areas. Poorer episodic memory was associated with age-related differences in central white matter regions. The observed multiple dissociations among specific age-sensitive cognitive skills and their putative neuroanatomical substrates support the view that age-related cognitive declines are unlikely to stem from a single cause.</description><subject>Adult</subject><subject>Adult. Elderly</subject><subject>Age Differences</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging (Individuals)</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - anatomy & histology</subject><subject>Brain - physiology</subject><subject>Brain Hemisphere Functions</subject><subject>Cognition</subject><subject>Cognition - physiology</subject><subject>Cognitive Ability</subject><subject>Cognitive Processes</subject><subject>Corpus Callosum - physiology</subject><subject>Developmental psychology</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Diffusion tensor imaging</subject><subject>Disconnection</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Inhibition</subject><subject>Inhibition (Psychology)</subject><subject>Integrity</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Occipital Lobe - physiology</subject><subject>Parietal Lobe - physiology</subject><subject>Prefrontal Cortex - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychomotor Performance - physiology</subject><subject>Short Term Memory</subject><subject>Task Analysis</subject><subject>Temporal Lobe - physiology</subject><subject>White matter</subject><issn>0028-3932</issn><issn>1873-3514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAUhiMEotPCGyDkDV01w3HsOAkLpKotFFSJDawtxz7JeJTYg50MzFPwynja0RRYsfLlfOc_lz_LziksKVDxdr10OAe_iTu98oPvrVoWAM0S6BKAPskWtK5YzkrKn2YLgKLOWcOKk-w0xjUA8LKon2cntKFC1KJcZL8ue-t68mNlJySjmiYMRDlDtO-dnax378i17ToM6CarBoLprqdIfEcC9ime_rYqWLVnI7GOmITPMb3IJvWJYbKYcEdGHH3YXRD8iXqe7BZJNzt9n3ZxXzJuEM2L7FmnhogvD-dZ9u3Dzder2_zuy8dPV5d3uRa0nnLecgShW65aVlbGNC0Yo1hVgqGmFJ1qqpZrVRpOO6ZA0brm0DAoadoWUsHOsvcPupu5HdHoNF5Qg9wEO6qwk15Z-XfE2ZXs_VYWgjNGIQmcHwSC_z5jnORoo8ZhUA79HKUQTVGyqn6spIOPMWB3LEJB7j2Va_mvp3LvqQQqk6dJ4PWfrT6mH0xMwJsDoKJWQxeU0zYeuaIALmrgiXv1wGGw-hi--VwLEM1-ottDOO19azHIqC06jcaG5Lk03v5vy78B4UrYzA</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Kennedy, Kristen M.</creator><creator>Raz, Naftali</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090201</creationdate><title>Aging white matter and cognition: Differential effects of regional variations in diffusion properties on memory, executive functions, and speed</title><author>Kennedy, Kristen M. ; Raz, Naftali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c618t-4b4e06cb4ab357dd9b0dda3750d1d56fa97b4ca5d41f3a0a1884093051200e163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Adult. Elderly</topic><topic>Age Differences</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aging</topic><topic>Aging (Individuals)</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - anatomy & histology</topic><topic>Brain - physiology</topic><topic>Brain Hemisphere Functions</topic><topic>Cognition</topic><topic>Cognition - physiology</topic><topic>Cognitive Ability</topic><topic>Cognitive Processes</topic><topic>Corpus Callosum - physiology</topic><topic>Developmental psychology</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Diffusion tensor imaging</topic><topic>Disconnection</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Inhibition</topic><topic>Inhibition (Psychology)</topic><topic>Integrity</topic><topic>Male</topic><topic>Memory - physiology</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Occipital Lobe - physiology</topic><topic>Parietal Lobe - physiology</topic><topic>Prefrontal Cortex - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychomotor Performance - physiology</topic><topic>Short Term Memory</topic><topic>Task Analysis</topic><topic>Temporal Lobe - physiology</topic><topic>White matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kennedy, Kristen M.</creatorcontrib><creatorcontrib>Raz, Naftali</creatorcontrib><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education Resources Information Center (ERIC)</collection><collection>ERIC</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuropsychologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kennedy, Kristen M.</au><au>Raz, Naftali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ860690</ericid><atitle>Aging white matter and cognition: Differential effects of regional variations in diffusion properties on memory, executive functions, and speed</atitle><jtitle>Neuropsychologia</jtitle><addtitle>Neuropsychologia</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>47</volume><issue>3</issue><spage>916</spage><epage>927</epage><pages>916-927</pages><issn>0028-3932</issn><eissn>1873-3514</eissn><coden>NUPSA6</coden><abstract>Disruption of cerebral white matter has been proposed as an explanation for age-related cognitive declines. However, the role of specific regions in specific cognitive declines remains unclear. We used diffusion tensor imaging to examine the associations between regional microstructural integrity of the white matter and performance on age-sensitive cognitive tasks in a sample of healthy adults (
N
=
52, age 19–81 years). White matter integrity was assessed by fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in multiple regions of interest (genu and splenium of corpus callosum, internal capsule limbs, prefrontal, temporal, superior/posterior parietal, occipital white matter) and related to processing speed, working memory, inhibition, task switching, and episodic memory. We found that age and regional white matter integrity differentially influenced cognitive performance. Age-related degradation in anterior brain areas was associated with decreased processing speed and poorer working memory, whereas reduced inhibition and greater task switching costs were linked to decline in posterior areas. Poorer episodic memory was associated with age-related differences in central white matter regions. The observed multiple dissociations among specific age-sensitive cognitive skills and their putative neuroanatomical substrates support the view that age-related cognitive declines are unlikely to stem from a single cause.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19166865</pmid><doi>10.1016/j.neuropsychologia.2009.01.001</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult. Elderly Age Differences Age Factors Aged Aging Aging (Individuals) Biological and medical sciences Brain Brain - anatomy & histology Brain - physiology Brain Hemisphere Functions Cognition Cognition - physiology Cognitive Ability Cognitive Processes Corpus Callosum - physiology Developmental psychology Diffusion Magnetic Resonance Imaging Diffusion tensor imaging Disconnection Female Fundamental and applied biological sciences. Psychology Humans Image Processing, Computer-Assisted Inhibition Inhibition (Psychology) Integrity Male Memory - physiology Middle Aged MRI Neurology Neuropsychological Tests Occipital Lobe - physiology Parietal Lobe - physiology Prefrontal Cortex - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - physiology Short Term Memory Task Analysis Temporal Lobe - physiology White matter |
| title | Aging white matter and cognition: Differential effects of regional variations in diffusion properties on memory, executive functions, and speed |
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