Cloning and Characterization of CYP51 from Mycobacterium avium

Mycobacterium avium complex (MAC) causes chronic lung disease in immunocompetent people and disseminated infection in patients with AIDS. MAC is intrinsically resistant to many conventional antimycobacterial agents, it develops drug resistance rapidly to macrolide antibiotics, and patients with MAC...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2006-08, Vol.35 (2), p.236-242
Hauptverfasser:	Pietila, Michael P, Vohra, Pawan K, Sanyal, Bharati, Wengenack, Nancy L, Raghavakaimal, Sreekumar, Thomas, Charles F., Jr
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - pharmacology Antifungal Agents - chemistry Antifungal Agents - pharmacology Azoles - chemistry Azoles - pharmacology Catalysis Cloning, Molecular Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - isolation & purification Cytochrome P-450 Enzyme System - metabolism Dose-Response Relationship, Drug Drug Resistance, Microbial Electron Spin Resonance Spectroscopy Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Macrolides - pharmacology Mass Spectrometry Microbial Sensitivity Tests Mycobacterium avium - enzymology Oxidoreductases - antagonists & inhibitors Oxidoreductases - genetics Oxidoreductases - isolation & purification Oxidoreductases - metabolism Recombinant Proteins - metabolism Sterol 14-Demethylase
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