Mapping of a Novel Susceptibility Locus Suggests a Role for MC3R and CTSZ in Human Tuberculosis

Tuberculosis remains a major cause of morbidity and mortality in the developing world. A better understanding of the mechanisms of disease protection could allow novel strategies to disease management and control. To identify human genomic loci with evidence of linkage to tuberculosis susceptibility...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2008-07, Vol.178 (2), p.203-207
Hauptverfasser:	Cooke, Graham S, Campbell, Sarah J, Bennett, Steve, Lienhardt, Christian, McAdam, Keith P. W. J, Sirugo, Giorgio, Sow, Oumou, Gustafson, Per, Mwangulu, Frank, van Helden, Paul, Fine, Paul, Hoal, Eileen G, Hill, Adrian V. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa, Western - epidemiology African Continental Ancestry Group - genetics Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood coagulation. Blood cells Case-Control Studies Cathepsin K Cathepsin Z Cathepsins - genetics Ethics Fundamental and applied biological sciences. Psychology Gene loci Genetic Linkage Genetic Predisposition to Disease - ethnology Genetic Predisposition to Disease - genetics Genetics Genomes H. Tuberculosis HIV Human immunodeficiency virus Humans Intensive care medicine Likelihood Functions Malawi - epidemiology Medical research Medical sciences Microsatellite Repeats Molecular and cellular biology Pathogenesis Pedigree Platelet Polymorphism, Genetic Receptor, Melanocortin, Type 3 - genetics Regression Analysis Siblings South Africa - epidemiology Tuberculosis Tuberculosis, Pulmonary - ethnology Tuberculosis, Pulmonary - genetics
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