Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt

C57BLKS/J (BLKS) mice are susceptible to islet exhaustion in insulin-resistant states as compared with C57BL6/J (B6) mice, as observed by the presence of the leptin receptor (Lepr) allele, Leprdb/db. Furthermore, DBA2/J (DBA) mice are also susceptible to beta-cell failure and share 25% of their geno...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	PathoGenetics 2009-01, Vol.2 (1), p.1-1, Article 1
Hauptverfasser:	Anderson, Abraham A, Helmering, Joan, Juan, Todd, Li, Chi-Ming, McCormick, Jocelyn, Graham, Melissa, Baker, Daniel M, Damore, Michael A, Véniant, Murielle M, Lloyd, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene expression Genetic aspects Genetic transcription Islands of Langerhans Type 2 diabetes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!