Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits

Aims Peripheral chemoreflex sensitivity is potentiated in both clinical and experimental chronic heart failure (CHF). NADPH oxidase-derived superoxide mediates angiotensin II (Ang II)-enhanced carotid body (CB) chemoreceptor sensitivity in CHF rabbits, and tempol, the superoxide dismutase (SOD) mime...

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Veröffentlicht in:	Cardiovascular research 2009-03, Vol.81 (4), p.678-685
Hauptverfasser:	Ding, Yanfeng, Li, Yu-Long, Zimmerman, Matthew C., Davisson, Robin L., Schultz, Harold D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Adenoviral vector Adenoviridae - genetics Animals Biological and medical sciences Blotting, Western Cardiology. Vascular system Carotid body Carotid Body - enzymology Carotid Body - physiopathology Chemoreceptor Chronic Disease Chronic heart failure Disease Models, Animal Electric Capacitance Fluorescent Antibody Technique Gene Transfer Techniques Genetic Vectors Glomus cell Heart Heart Failure - enzymology Heart Failure - physiopathology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Hypoxia - enzymology Hypoxia - physiopathology Kidney - innervation Male Medical sciences Original Potassium - metabolism Rabbits Reflex Signal Transduction Superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1 Superoxides - metabolism Sympathetic nerve activity Sympathetic Nervous System - physiopathology
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