Glycosynthases Enable a Highly Efficient Chemoenzymatic Synthesis of N-Glycoproteins Carrying Intact Natural N-Glycans

Homogeneous N-glycoproteins carrying defined natural N-glycans are essential for detailed structural and functional studies. The transglycosylation activity of the endo-β-N-acetylglucosaminidases from Arthrobacter protophormiae (Endo-A) and Mucor hiemalis (Endo-M) holds great potential for glycoprot...

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Veröffentlicht in:	Journal of the American Chemical Society 2009-02, Vol.131 (6), p.2214-2223
Hauptverfasser:	Huang, Wei, Li, Cishan, Li, Bing, Umekawa, Midori, Yamamoto, Kenji, Zhang, Xinyu, Wang, Lai-Xi
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthrobacter - enzymology Carbohydrate Sequence Glycoproteins - chemical synthesis Glycoproteins - metabolism Glycoside Hydrolases - chemistry Glycoside Hydrolases - metabolism Glycosylation Models, Molecular Molecular Sequence Data Mucor - enzymology Oligosaccharides - chemical synthesis Oligosaccharides - metabolism Oxazoles - chemistry Oxazoles - metabolism Polysaccharides - chemical synthesis Polysaccharides - metabolism
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