Transfection activity of layer-by-layer plasmid DNA/poly(ethylenimine) films deposited on PLGA microparticles

Layer-by-layer (LbL) assemblies of DNA and polycations on the surface of colloidal templates can be used for gene delivery. Plasmid DNA encoding for secreted alkaline phosphatase (SEAP) was used to deposit LbL films with poly(ethylenimine) (PEI) on the surface of polystyrene and poly(lactide-co-glyc...

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Veröffentlicht in:	International journal of pharmaceutics 2009-01, Vol.365 (1), p.44-52
Hauptverfasser:	Kakade, Sandeep, Manickam, Devika Soundara, Handa, Hitesh, Mao, Guangzhao, Oupický, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - genetics Animals Biological and medical sciences Cell Line DNA - administration & dosage Gene Dosage Gene Expression Regulation, Enzymologic Gene Transfer Techniques General pharmacology Lactic Acid - chemistry Layer-by-layer Macrophages Medical sciences Mice Microparticles Microspheres Phagocytosis Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Plasmid DNA Plasmids - administration & dosage PLGA Polyethyleneimine - chemistry Polyglycolic Acid - chemistry Polylactic Acid-Polyglycolic Acid Copolymer Polystyrenes - chemistry Transfection
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