Smad Ubiquitination Regulatory Factor 2 Promotes Metastasis of Breast Cancer Cells by Enhancing Migration and Invasiveness

Controlled protein degradation mediated by ubiquitin/proteasome system (UPS) plays a crucial role in modulating a broad range of cellular responses. Dysregulation of the UPS often accompanies tumorigenesis and progression. Here, we report that Smad ubiquitination regulatory factor 2 (Smurf2), a HECT...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009-02, Vol.69 (3), p.735-740
Hauptverfasser:	CHAOYANG JIN, YANG, Yu-An, ANVER, Miriam R, MORRIS, Nicole, XIANGCHUN WANG, ZHANG, Ying E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Breast Neoplasms - enzymology Breast Neoplasms - pathology Cell Line, Tumor Cell Movement - physiology Female Gynecology. Andrology. Obstetrics Humans Male Mammary gland diseases Medical sciences Neoplasm Invasiveness Neoplasm Metastasis Ovarian Neoplasms - enzymology Ovarian Neoplasms - pathology Pharmacology. Drug treatments Prostatic Neoplasms - enzymology Prostatic Neoplasms - pathology Tumors Ubiquitin-Protein Ligases - biosynthesis
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