Multiple regions within 8q24 independently affect risk for prostate cancer

After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five of them previously undescribed, spanning 430 kb an...

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Veröffentlicht in:	Nature genetics 2007-05, Vol.39 (5), p.638-644
Hauptverfasser:	Haiman, Christopher A, Patterson, Nick, Freedman, Matthew L, Myers, Simon R, Pike, Malcolm C, Waliszewska, Alicja, Neubauer, Julie, Tandon, Arti, Schirmer, Christine, McDonald, Gavin J, Greenway, Steven C, Stram, Daniel O, Le Marchand, Loic, Kolonel, Laurence N, Frasco, Melissa, Wong, David, Pooler, Loreall C, Ardlie, Kristin, Oakley-Girvan, Ingrid, Whittemore, Alice S, Cooney, Kathleen A, John, Esther M, Ingles, Sue A, Altshuler, David, Henderson, Brian E, Reich, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Black or African American Cancer Research Chromosomes, Human, Pair 8 - genetics Classical genetics, quantitative genetics, hybrids Ethnicity - genetics Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetic diversity Genetic markers Genetic Predisposition to Disease - genetics Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genomics - methods Genotype Genotype & phenotype Genotypes Gynecology. Andrology. Obstetrics Haplotypes - genetics Health aspects Health risks Human Genetics Humans letter Male Male genital diseases Medical sciences Methods, theories and miscellaneous Nephrology. Urinary tract diseases Odds Ratio Polymorphism, Single Nucleotide Prostate cancer Prostatic Neoplasms - genetics Risk Factors Tumors Tumors of the urinary system United States Urinary tract. Prostate gland White People
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