Multiple regions within 8q24 independently affect risk for prostate cancer
After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five of them previously undescribed, spanning 430 kb an...
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| Veröffentlicht in: | Nature genetics 2007-05, Vol.39 (5), p.638-644 |
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| creator | Haiman, Christopher A Patterson, Nick Freedman, Matthew L Myers, Simon R Pike, Malcolm C Waliszewska, Alicja Neubauer, Julie Tandon, Arti Schirmer, Christine McDonald, Gavin J Greenway, Steven C Stram, Daniel O Le Marchand, Loic Kolonel, Laurence N Frasco, Melissa Wong, David Pooler, Loreall C Ardlie, Kristin Oakley-Girvan, Ingrid Whittemore, Alice S Cooney, Kathleen A John, Esther M Ingles, Sue A Altshuler, David Henderson, Brian E Reich, David |
| description | After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (
P
= 7.9 × 10
−19
for the strongest association, and
P
< 1.5 × 10
−4
for five of the variants, after controlling for each of the others). The variants define common genotypes that span a more than fivefold range of susceptibility to cancer in some populations. None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein. |
| doi_str_mv | 10.1038/ng2015 |
| format | Article |
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P
= 7.9 × 10
−19
for the strongest association, and
P
< 1.5 × 10
−4
for five of the variants, after controlling for each of the others). The variants define common genotypes that span a more than fivefold range of susceptibility to cancer in some populations. None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng2015</identifier><identifier>PMID: 17401364</identifier><identifier>CODEN: NGENEC</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Agriculture ; Animal Genetics and Genomics ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Black or African American ; Cancer Research ; Chromosomes, Human, Pair 8 - genetics ; Classical genetics, quantitative genetics, hybrids ; Ethnicity - genetics ; Fundamental and applied biological sciences. Psychology ; Gene Function ; Genetic aspects ; Genetic diversity ; Genetic markers ; Genetic Predisposition to Disease - genetics ; Genetic Variation ; Genetics of eukaryotes. Biological and molecular evolution ; Genomics - methods ; Genotype ; Genotype & phenotype ; Genotypes ; Gynecology. Andrology. Obstetrics ; Haplotypes - genetics ; Health aspects ; Health risks ; Human Genetics ; Humans ; letter ; Male ; Male genital diseases ; Medical sciences ; Methods, theories and miscellaneous ; Nephrology. Urinary tract diseases ; Odds Ratio ; Polymorphism, Single Nucleotide ; Prostate cancer ; Prostatic Neoplasms - genetics ; Risk Factors ; Tumors ; Tumors of the urinary system ; United States ; Urinary tract. Prostate gland ; White People</subject><ispartof>Nature genetics, 2007-05, Vol.39 (5), p.638-644</ispartof><rights>Springer Nature America, Inc. 2007</rights><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c685t-c6bb90f3023f217f8ebe1d9c77df07c802f296ea800128b3d15c6067ee4482f43</citedby><cites>FETCH-LOGICAL-c685t-c6bb90f3023f217f8ebe1d9c77df07c802f296ea800128b3d15c6067ee4482f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ng2015$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ng2015$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18733453$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17401364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haiman, Christopher A</creatorcontrib><creatorcontrib>Patterson, Nick</creatorcontrib><creatorcontrib>Freedman, Matthew L</creatorcontrib><creatorcontrib>Myers, Simon R</creatorcontrib><creatorcontrib>Pike, Malcolm C</creatorcontrib><creatorcontrib>Waliszewska, Alicja</creatorcontrib><creatorcontrib>Neubauer, Julie</creatorcontrib><creatorcontrib>Tandon, Arti</creatorcontrib><creatorcontrib>Schirmer, Christine</creatorcontrib><creatorcontrib>McDonald, Gavin J</creatorcontrib><creatorcontrib>Greenway, Steven C</creatorcontrib><creatorcontrib>Stram, Daniel O</creatorcontrib><creatorcontrib>Le Marchand, Loic</creatorcontrib><creatorcontrib>Kolonel, Laurence N</creatorcontrib><creatorcontrib>Frasco, Melissa</creatorcontrib><creatorcontrib>Wong, David</creatorcontrib><creatorcontrib>Pooler, Loreall C</creatorcontrib><creatorcontrib>Ardlie, Kristin</creatorcontrib><creatorcontrib>Oakley-Girvan, Ingrid</creatorcontrib><creatorcontrib>Whittemore, Alice S</creatorcontrib><creatorcontrib>Cooney, Kathleen A</creatorcontrib><creatorcontrib>John, Esther M</creatorcontrib><creatorcontrib>Ingles, Sue A</creatorcontrib><creatorcontrib>Altshuler, David</creatorcontrib><creatorcontrib>Henderson, Brian E</creatorcontrib><creatorcontrib>Reich, David</creatorcontrib><title>Multiple regions within 8q24 independently affect risk for prostate cancer</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (
P
= 7.9 × 10
−19
for the strongest association, and
P
< 1.5 × 10
−4
for five of the variants, after controlling for each of the others). The variants define common genotypes that span a more than fivefold range of susceptibility to cancer in some populations. None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein.</description><subject>Agriculture</subject><subject>Animal Genetics and Genomics</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Black or African American</subject><subject>Cancer Research</subject><subject>Chromosomes, Human, Pair 8 - genetics</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Ethnicity - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Function</subject><subject>Genetic aspects</subject><subject>Genetic diversity</subject><subject>Genetic markers</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetic Variation</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genomics - methods</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Haplotypes - genetics</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>letter</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Methods, theories and miscellaneous</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Odds Ratio</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Risk Factors</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>United States</subject><subject>Urinary tract. 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Psychology</topic><topic>Gene Function</topic><topic>Genetic aspects</topic><topic>Genetic diversity</topic><topic>Genetic markers</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetic Variation</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genomics - methods</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Haplotypes - genetics</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>letter</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Methods, theories and miscellaneous</topic><topic>Nephrology. 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We identified seven risk variants, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (
P
= 7.9 × 10
−19
for the strongest association, and
P
< 1.5 × 10
−4
for five of the variants, after controlling for each of the others). The variants define common genotypes that span a more than fivefold range of susceptibility to cancer in some populations. None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>17401364</pmid><doi>10.1038/ng2015</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1061-4036 |
| ispartof | Nature genetics, 2007-05, Vol.39 (5), p.638-644 |
| issn | 1061-4036 1546-1718 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2638766 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Black or African American Cancer Research Chromosomes, Human, Pair 8 - genetics Classical genetics, quantitative genetics, hybrids Ethnicity - genetics Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetic diversity Genetic markers Genetic Predisposition to Disease - genetics Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genomics - methods Genotype Genotype & phenotype Genotypes Gynecology. Andrology. Obstetrics Haplotypes - genetics Health aspects Health risks Human Genetics Humans letter Male Male genital diseases Medical sciences Methods, theories and miscellaneous Nephrology. Urinary tract diseases Odds Ratio Polymorphism, Single Nucleotide Prostate cancer Prostatic Neoplasms - genetics Risk Factors Tumors Tumors of the urinary system United States Urinary tract. Prostate gland White People |
| title | Multiple regions within 8q24 independently affect risk for prostate cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T05%3A06%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multiple%20regions%20within%208q24%20independently%20affect%20risk%20for%20prostate%20cancer&rft.jtitle=Nature%20genetics&rft.au=Haiman,%20Christopher%20A&rft.date=2007-05-01&rft.volume=39&rft.issue=5&rft.spage=638&rft.epage=644&rft.pages=638-644&rft.issn=1061-4036&rft.eissn=1546-1718&rft.coden=NGENEC&rft_id=info:doi/10.1038/ng2015&rft_dat=%3Cgale_pubme%3EA183393596%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222633150&rft_id=info:pmid/17401364&rft_galeid=A183393596&rfr_iscdi=true |