Crystal Structures of Monomeric Actin Bound to Cytochalasin D

The fungal toxin cytochalasin D (CD) interferes with the normal dynamics of the actin cytoskeleton by binding to the barbed end of actin filaments. Despite its widespread use as a tool for studying actin-mediated processes, the exact location and nature of its binding to actin have not been previous...

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Veröffentlicht in:	Journal of molecular biology 2008-12, Vol.384 (4), p.848-864
Hauptverfasser:	Nair, Usha B., Joel, Peteranne B., Wan, Qun, Lowey, Susan, Rould, Mark A., Trybus, Kathleen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Actins - chemistry Actins - metabolism Adenosine Triphosphate - metabolism Binding Sites Crystallography, X-Ray cytochalasin Cytochalasin D - metabolism domain motions filament capping fungal toxin Hydrolysis Models, Molecular Protein Binding Protein Conformation Protein Structure, Tertiary
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