Necessity for Afferent Activity to Maintain Eye-Specific Segregation in Ferret Lateral Geniculate Nucleus
In the adult mammal, retinal ganglion cell axon arbors are restricted to eye-specific layers in the lateral geniculate nucleus. Blocking neuronal activity early in development prevents this segregation from occurring. To test whether activity is also required to maintain eye-specific segregation, ga...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2000-03, Vol.287 (5462), p.2479-2482 |
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| description | In the adult mammal, retinal ganglion cell axon arbors are restricted to eye-specific layers in the lateral geniculate nucleus. Blocking neuronal activity early in development prevents this segregation from occurring. To test whether activity is also required to maintain eye-specific segregation, ganglion cell activity was blocked after segregation was established. This caused desegregation, so that both eyes' axons became concentrated in lamina A, normally occupied only by contralateral afferents. These results show that an activity-dependent process is necessary for maintaining eye-specific segregation and suggest that activity-independent cues may favor lamina A as the target for arborization of afferents from both eyes. |
| doi_str_mv | 10.1126/science.287.5462.2479 |
| format | Article |
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These results show that an activity-dependent process is necessary for maintaining eye-specific segregation and suggest that activity-independent cues may favor lamina A as the target for arborization of afferents from both eyes.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.287.5462.2479</identifier><identifier>PMID: 10741966</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Aminobutyrates - pharmacology ; Animals ; Axons ; Axons - physiology ; Axons - ultrastructure ; Biological and medical sciences ; Cell separation ; Competition ; Competitive advantage ; Desegregation ; Excitatory Amino Acid Agonists - pharmacology ; Eye and associated structures. Visual pathways and centers. 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Psychology ; Ganglia ; Geniculate Bodies - anatomy & histology ; Geniculate Bodies - drug effects ; Geniculate Bodies - growth & development ; Geniculate Bodies - physiology ; Injections ; Mammals ; Neurology ; Neuroscience ; Photographic slides ; Retina ; Retina - drug effects ; Retina - growth & development ; Retinal Ganglion Cells - cytology ; Retinal Ganglion Cells - drug effects ; Retinal Ganglion Cells - physiology ; RNA ; Thalamus ; Transgenes ; Vertebrates: nervous system and sense organs ; Visual Pathways - growth & development ; Visual Pathways - physiology</subject><ispartof>Science (American Association for the Advancement of Science), 2000-03, Vol.287 (5462), p.2479-2482</ispartof><rights>Copyright 2000 American Association for the Advancement of Science</rights><rights>2000 INIST-CNRS</rights><rights>COPYRIGHT 2000 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Mar 31, 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c847t-da192b9fe913481a60f05267108efb01dc1654f0e62f82d695e09d698b4b1fca3</citedby><cites>FETCH-LOGICAL-c847t-da192b9fe913481a60f05267108efb01dc1654f0e62f82d695e09d698b4b1fca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3074764$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3074764$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1333455$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10741966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chapman, Barbara</creatorcontrib><title>Necessity for Afferent Activity to Maintain Eye-Specific Segregation in Ferret Lateral Geniculate Nucleus</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>In the adult mammal, retinal ganglion cell axon arbors are restricted to eye-specific layers in the lateral geniculate nucleus. Blocking neuronal activity early in development prevents this segregation from occurring. To test whether activity is also required to maintain eye-specific segregation, ganglion cell activity was blocked after segregation was established. This caused desegregation, so that both eyes' axons became concentrated in lamina A, normally occupied only by contralateral afferents. These results show that an activity-dependent process is necessary for maintaining eye-specific segregation and suggest that activity-independent cues may favor lamina A as the target for arborization of afferents from both eyes.</description><subject>Aminobutyrates - pharmacology</subject><subject>Animals</subject><subject>Axons</subject><subject>Axons - physiology</subject><subject>Axons - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Cell separation</subject><subject>Competition</subject><subject>Competitive advantage</subject><subject>Desegregation</subject><subject>Excitatory Amino Acid Agonists - pharmacology</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Ferrets</subject><subject>Ferrets - growth & development</subject><subject>Ferrets - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia</subject><subject>Geniculate Bodies - anatomy & histology</subject><subject>Geniculate Bodies - drug effects</subject><subject>Geniculate Bodies - growth & development</subject><subject>Geniculate Bodies - physiology</subject><subject>Injections</subject><subject>Mammals</subject><subject>Neurology</subject><subject>Neuroscience</subject><subject>Photographic slides</subject><subject>Retina</subject><subject>Retina - drug effects</subject><subject>Retina - growth & development</subject><subject>Retinal Ganglion Cells - cytology</subject><subject>Retinal Ganglion Cells - drug effects</subject><subject>Retinal Ganglion Cells - physiology</subject><subject>RNA</subject><subject>Thalamus</subject><subject>Transgenes</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Visual Pathways - growth & development</subject><subject>Visual Pathways - 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Segregation in Ferret Lateral Geniculate Nucleus</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2000-03-31</date><risdate>2000</risdate><volume>287</volume><issue>5462</issue><spage>2479</spage><epage>2482</epage><pages>2479-2482</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>In the adult mammal, retinal ganglion cell axon arbors are restricted to eye-specific layers in the lateral geniculate nucleus. Blocking neuronal activity early in development prevents this segregation from occurring. To test whether activity is also required to maintain eye-specific segregation, ganglion cell activity was blocked after segregation was established. This caused desegregation, so that both eyes' axons became concentrated in lamina A, normally occupied only by contralateral afferents. These results show that an activity-dependent process is necessary for maintaining eye-specific segregation and suggest that activity-independent cues may favor lamina A as the target for arborization of afferents from both eyes.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>10741966</pmid><doi>10.1126/science.287.5462.2479</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2000-03, Vol.287 (5462), p.2479-2482 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Aminobutyrates - pharmacology Animals Axons Axons - physiology Axons - ultrastructure Biological and medical sciences Cell separation Competition Competitive advantage Desegregation Excitatory Amino Acid Agonists - pharmacology Eye and associated structures. Visual pathways and centers. Vision Ferrets Ferrets - growth & development Ferrets - physiology Fundamental and applied biological sciences. Psychology Ganglia Geniculate Bodies - anatomy & histology Geniculate Bodies - drug effects Geniculate Bodies - growth & development Geniculate Bodies - physiology Injections Mammals Neurology Neuroscience Photographic slides Retina Retina - drug effects Retina - growth & development Retinal Ganglion Cells - cytology Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - physiology RNA Thalamus Transgenes Vertebrates: nervous system and sense organs Visual Pathways - growth & development Visual Pathways - physiology |
| title | Necessity for Afferent Activity to Maintain Eye-Specific Segregation in Ferret Lateral Geniculate Nucleus |
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