Design of Combination Angiotensin Receptor Blocker and Angiotensin-Converting Enzyme Inhibitor for Treatment of Diabetic Nephropathy (VA NEPHRON-D)

Both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) can slow the progression of diabetic nephropathy. Even with ACEI or ARB treatment, the proportion of patients who progress to end-stage renal disease (ESRD) remains high. Interventions that achieve more co...

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Veröffentlicht in:	Clinical journal of the American Society of Nephrology 2009-02, Vol.4 (2), p.361-368
Hauptverfasser:	Fried, Linda F, Duckworth, William, Zhang, Jane Hongyuan, O'Connor, Theresa, Brophy, Mary, Emanuele, Nicholas, Huang, Grant D, McCullough, Peter A, Palevsky, Paul M, Seliger, Stephen, Warren, Stuart R, Peduzzi, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Type 1 Receptor Blockers - adverse effects Angiotensin II Type 1 Receptor Blockers - therapeutic use Angiotensin-Converting Enzyme Inhibitors - adverse effects Angiotensin-Converting Enzyme Inhibitors - therapeutic use Diabetes and the Kidney Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - mortality Diabetes Mellitus, Type 2 - physiopathology Diabetic Nephropathies - drug therapy Diabetic Nephropathies - etiology Diabetic Nephropathies - mortality Diabetic Nephropathies - physiopathology Disease Progression Double-Blind Method Drug Therapy, Combination Glomerular Filtration Rate - drug effects Humans Hyperkalemia - chemically induced Kidney Failure, Chronic - etiology Kidney Failure, Chronic - mortality Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - prevention & control Kidney Transplantation Lisinopril - adverse effects Lisinopril - therapeutic use Losartan - adverse effects Losartan - therapeutic use Prospective Studies Proteinuria - drug therapy Proteinuria - etiology Proteinuria - mortality Proteinuria - physiopathology Renal Dialysis Research Design Time Factors Treatment Outcome United States United States Department of Veterans Affairs
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