Association of Gene Variants With Incident Myocardial Infarction in the Cardiovascular Health Study

OBJECTIVE—We asked whether single nucleotide polymorphisms (SNPs) that had been nominally associated with cardiovascular disease in antecedent studies were also associated with cardiovascular disease in a population-based prospective study of 4522 individuals aged 65 or older. METHODS AND RESULTS—Ba...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2008-01, Vol.28 (1), p.173-179
Hauptverfasser:	Shiffman, Dov, O’Meara, Ellen S, Bare, Lance A, Rowland, Charles M, Louie, Judy Z, Arellano, Andre R, Lumley, Thomas, Rice, Kenneth, Iakoubova, Olga, Luke, May M, Young, Bradford A, Malloy, Mary J, Kane, John P, Ellis, Stephen G, Tracy, Russell P, Devlin, James J, Psaty, Bruce M
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Aged Aged, 80 and over Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Coronary Disease - genetics Coronary heart disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous European Continental Ancestry Group Female Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Heart Humans Longitudinal Studies Male Medical sciences Myocardial Infarction - genetics National Heart, Lung, and Blood Institute (U.S.) Neurology Polymorphism, Single Nucleotide - genetics Proportional Hazards Models United States - epidemiology Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:	OBJECTIVE—We asked whether single nucleotide polymorphisms (SNPs) that had been nominally associated with cardiovascular disease in antecedent studies were also associated with cardiovascular disease in a population-based prospective study of 4522 individuals aged 65 or older. METHODS AND RESULTS—Based on antecedent studies, we prespecified a risk allele and an inheritance model for each of 74 SNPs. We then tested the association of these SNPs with myocardial infarction (MI) in the Cardiovascular Health Study (CHS). The prespecified risk alleles of 8 SNPs were nominally associated (1-sided P
ISSN:	1079-5642 1524-4636
DOI:	10.1161/ATVBAHA.107.153981