RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells
The relationship between NF- κ B and resistance to radiation treatment in many tumor cell types has been generally well recognized. However, which members of the NF- κ B family contribute to radiation resistance is unclear. In the present study, we demonstrate that RelB plays an important radioprote...
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| Veröffentlicht in: | Oncogene 2006-03, Vol.25 (10), p.1554-1559 |
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| creator | Josson, S Xu, Y Fang, F Dhar, S K St Clair, D K St Clair, W H |
| description | The relationship between NF-
κ
B and resistance to radiation treatment in many tumor cell types has been generally well recognized. However, which members of the NF-
κ
B family contribute to radiation resistance is unclear. In the present study, we demonstrate that RelB plays an important radioprotective role in aggressive prostate cancer cells, in part by the induction of antioxidant and antiapoptotic manganese superoxide dismutase (MnSOD) gene. RelB is both constitutively present and is inducible by radiation in aggressive prostate cancer cells. Using ectopically expressed dominant negative inhibitor, p100 mutant, and the siRNA approach, we demonstrate that selective inhibition of RelB significantly decreases the levels of MnSOD resulting in a significant increase in the sensitivity of prostate cancer cells to radiation treatment. These results demonstrate that RelB plays an important role in redox regulation of the cell and protects aggressive prostate cancer cells against radiation-induced cell death. Thus, inhibition of RelB could be a novel mechanism to radiosensitize prostate cancer. |
| doi_str_mv | 10.1038/sj.onc.1209186 |
| format | Article |
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κ
B and resistance to radiation treatment in many tumor cell types has been generally well recognized. However, which members of the NF-
κ
B family contribute to radiation resistance is unclear. In the present study, we demonstrate that RelB plays an important radioprotective role in aggressive prostate cancer cells, in part by the induction of antioxidant and antiapoptotic manganese superoxide dismutase (MnSOD) gene. RelB is both constitutively present and is inducible by radiation in aggressive prostate cancer cells. Using ectopically expressed dominant negative inhibitor, p100 mutant, and the siRNA approach, we demonstrate that selective inhibition of RelB significantly decreases the levels of MnSOD resulting in a significant increase in the sensitivity of prostate cancer cells to radiation treatment. These results demonstrate that RelB plays an important role in redox regulation of the cell and protects aggressive prostate cancer cells against radiation-induced cell death. Thus, inhibition of RelB could be a novel mechanism to radiosensitize prostate cancer.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1209186</identifier><identifier>PMID: 16261162</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Antioxidants ; Apoptosis ; Biological and medical sciences ; Cell Biology ; Cell death ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Enzyme Induction - radiation effects ; Fundamental and applied biological sciences. Psychology ; Gamma Rays ; Gene Expression Regulation, Neoplastic - radiation effects ; Gynecology. Andrology. Obstetrics ; Human Genetics ; Humans ; Internal Medicine ; Ionizing radiation ; Male ; Male genital diseases ; Manganese ; Medical sciences ; Medicine ; Medicine & Public Health ; Molecular and cellular biology ; Nephrology. Urinary tract diseases ; NF-κB protein ; Oncology ; Oxidative Stress - radiation effects ; Promoter Regions, Genetic ; Prostate cancer ; Prostatic Neoplasms - enzymology ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - radiotherapy ; Proteins ; Radiation therapy ; Radiation Tolerance ; RelB protein ; RNA, Messenger - metabolism ; short-communication ; siRNA ; Superoxide dismutase ; Superoxide Dismutase - biosynthesis ; Superoxide Dismutase - genetics ; Superoxide Dismutase - radiation effects ; Transcription Factor RelB - antagonists & inhibitors ; Transcription Factor RelB - physiology ; Transcription Factor RelB - radiation effects ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>Oncogene, 2006-03, Vol.25 (10), p.1554-1559</ispartof><rights>Springer Nature Limited 2006</rights><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 9, 2006</rights><rights>Nature Publishing Group 2006.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-5dec4aa6697b5c5af0dda54bbe4e6fbf2c78f9a6e6d14f9e51532021cc25277d3</citedby><cites>FETCH-LOGICAL-c605t-5dec4aa6697b5c5af0dda54bbe4e6fbf2c78f9a6e6d14f9e51532021cc25277d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17585472$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16261162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Josson, S</creatorcontrib><creatorcontrib>Xu, Y</creatorcontrib><creatorcontrib>Fang, F</creatorcontrib><creatorcontrib>Dhar, S K</creatorcontrib><creatorcontrib>St Clair, D K</creatorcontrib><creatorcontrib>St Clair, W H</creatorcontrib><title>RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>The relationship between NF-
κ
B and resistance to radiation treatment in many tumor cell types has been generally well recognized. However, which members of the NF-
κ
B family contribute to radiation resistance is unclear. In the present study, we demonstrate that RelB plays an important radioprotective role in aggressive prostate cancer cells, in part by the induction of antioxidant and antiapoptotic manganese superoxide dismutase (MnSOD) gene. RelB is both constitutively present and is inducible by radiation in aggressive prostate cancer cells. Using ectopically expressed dominant negative inhibitor, p100 mutant, and the siRNA approach, we demonstrate that selective inhibition of RelB significantly decreases the levels of MnSOD resulting in a significant increase in the sensitivity of prostate cancer cells to radiation treatment. These results demonstrate that RelB plays an important role in redox regulation of the cell and protects aggressive prostate cancer cells against radiation-induced cell death. Thus, inhibition of RelB could be a novel mechanism to radiosensitize prostate cancer.</description><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Cell Biology</subject><subject>Cell death</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Enzyme Induction - radiation effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gamma Rays</subject><subject>Gene Expression Regulation, Neoplastic - radiation effects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Ionizing radiation</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Manganese</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Molecular and cellular biology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>NF-κB protein</subject><subject>Oncology</subject><subject>Oxidative Stress - radiation effects</subject><subject>Promoter Regions, Genetic</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - enzymology</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>Proteins</subject><subject>Radiation therapy</subject><subject>Radiation Tolerance</subject><subject>RelB protein</subject><subject>RNA, Messenger - metabolism</subject><subject>short-communication</subject><subject>siRNA</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - biosynthesis</subject><subject>Superoxide Dismutase - genetics</subject><subject>Superoxide Dismutase - radiation effects</subject><subject>Transcription Factor RelB - antagonists & inhibitors</subject><subject>Transcription Factor RelB - physiology</subject><subject>Transcription Factor RelB - radiation effects</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. 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Action of oncogenes and antioncogenes</topic><topic>Enzyme Induction - radiation effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gamma Rays</topic><topic>Gene Expression Regulation, Neoplastic - radiation effects</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Ionizing radiation</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Manganese</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Molecular and cellular biology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>NF-κB protein</topic><topic>Oncology</topic><topic>Oxidative Stress - radiation effects</topic><topic>Promoter Regions, Genetic</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - enzymology</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - radiotherapy</topic><topic>Proteins</topic><topic>Radiation therapy</topic><topic>Radiation Tolerance</topic><topic>RelB protein</topic><topic>RNA, Messenger - metabolism</topic><topic>short-communication</topic><topic>siRNA</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - biosynthesis</topic><topic>Superoxide Dismutase - genetics</topic><topic>Superoxide Dismutase - radiation effects</topic><topic>Transcription Factor RelB - antagonists & inhibitors</topic><topic>Transcription Factor RelB - physiology</topic><topic>Transcription Factor RelB - radiation effects</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Josson, S</creatorcontrib><creatorcontrib>Xu, Y</creatorcontrib><creatorcontrib>Fang, F</creatorcontrib><creatorcontrib>Dhar, S K</creatorcontrib><creatorcontrib>St Clair, D K</creatorcontrib><creatorcontrib>St Clair, W H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Josson, S</au><au>Xu, Y</au><au>Fang, F</au><au>Dhar, S K</au><au>St Clair, D K</au><au>St Clair, W H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2006-03-09</date><risdate>2006</risdate><volume>25</volume><issue>10</issue><spage>1554</spage><epage>1559</epage><pages>1554-1559</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>The relationship between NF-
κ
B and resistance to radiation treatment in many tumor cell types has been generally well recognized. However, which members of the NF-
κ
B family contribute to radiation resistance is unclear. In the present study, we demonstrate that RelB plays an important radioprotective role in aggressive prostate cancer cells, in part by the induction of antioxidant and antiapoptotic manganese superoxide dismutase (MnSOD) gene. RelB is both constitutively present and is inducible by radiation in aggressive prostate cancer cells. Using ectopically expressed dominant negative inhibitor, p100 mutant, and the siRNA approach, we demonstrate that selective inhibition of RelB significantly decreases the levels of MnSOD resulting in a significant increase in the sensitivity of prostate cancer cells to radiation treatment. These results demonstrate that RelB plays an important role in redox regulation of the cell and protects aggressive prostate cancer cells against radiation-induced cell death. Thus, inhibition of RelB could be a novel mechanism to radiosensitize prostate cancer.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16261162</pmid><doi>10.1038/sj.onc.1209186</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Apoptosis Biological and medical sciences Cell Biology Cell death Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Enzyme Induction - radiation effects Fundamental and applied biological sciences. Psychology Gamma Rays Gene Expression Regulation, Neoplastic - radiation effects Gynecology. Andrology. Obstetrics Human Genetics Humans Internal Medicine Ionizing radiation Male Male genital diseases Manganese Medical sciences Medicine Medicine & Public Health Molecular and cellular biology Nephrology. Urinary tract diseases NF-κB protein Oncology Oxidative Stress - radiation effects Promoter Regions, Genetic Prostate cancer Prostatic Neoplasms - enzymology Prostatic Neoplasms - genetics Prostatic Neoplasms - radiotherapy Proteins Radiation therapy Radiation Tolerance RelB protein RNA, Messenger - metabolism short-communication siRNA Superoxide dismutase Superoxide Dismutase - biosynthesis Superoxide Dismutase - genetics Superoxide Dismutase - radiation effects Transcription Factor RelB - antagonists & inhibitors Transcription Factor RelB - physiology Transcription Factor RelB - radiation effects Tumors Tumors of the urinary system Urinary tract. Prostate gland |
| title | RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells |
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