Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

Functional proteomic profiling reveals several brain hydrolase targets for endocannabinoid biosynthesis inhibitors. The endocannabinoid 2-arachidonoylglycerol (2-AG) has been implicated as a key retrograde mediator in the nervous system based on pharmacological studies using inhibitors of the 2-AG b...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-11, Vol.18 (22), p.5838-5841
Hauptverfasser:	Hoover, Heather S., Blankman, Jacqueline L., Niessen, Sherry, Cravatt, Benjamin F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activity-based proteomics Arachidonic Acids - antagonists & inhibitors Arachidonic Acids - biosynthesis Biological and medical sciences Biosynthesis Brain - enzymology Cannabinoid Receptor Modulators - antagonists & inhibitors Cannabinoid Receptor Modulators - biosynthesis Cyclohexanones - pharmacology Endocannabinoid Endocannabinoids Glycerides - antagonists & inhibitors Glycerides - biosynthesis Humans Inhibitor Isoenzymes - antagonists & inhibitors Lactones - pharmacology Lipase Lipase - antagonists & inhibitors Medical sciences Miscellaneous Molecular Structure Pharmacology. Drug treatments Receptor, Cannabinoid, CB1 - metabolism Serine Proteinase Inhibitors - pharmacology
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