Arsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress response

The conserved Target Of Rapamycin (TOR) growth control signaling pathway is a major regulator of genes required for protein synthesis. The ubiquitous toxic metalloid arsenic, as well as mercury and nickel, are shown here to efficiently inhibit the rapamycin-sensitive TORC1 (TOR complex 1) protein ki...

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Veröffentlicht in:	Molecular biology of the cell 2009-02, Vol.20 (3), p.1048-1057
Hauptverfasser:	Hosiner, Dagmar, Lempiäinen, Harri, Reiter, Wolfgang, Urban, Joerg, Loewith, Robbie, Ammerer, Gustav, Schweyen, Rudolf, Shore, David, Schüller, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Arsenic - toxicity Base Sequence Chromatin - metabolism Cytosol - drug effects Cytosol - metabolism Gene Expression Regulation, Fungal - drug effects Models, Biological Molecular Sequence Data Phosphorylation - drug effects Protein Kinases - genetics Protein Kinases - metabolism Protein Transport - drug effects Regulatory Sequences, Nucleic Acid - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - antagonists & inhibitors Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Stress, Physiological - drug effects Transcription, Genetic - drug effects
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